| Gene Information | |
|---|---|
| Gene Name | HOOK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 719 |
| Protein Names | Protein Hook homolog 2 (h-hook2) (hHK2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000095066 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q96ED9 |
| Gene Card | HOOK2 |
| Uniprot ID | Q96ED9 |
| Pfam | PF05622; PF19047 |
| In ASD | no |
| Allosteric Prediction | no (-0.661848168) |
| Ortholog in Animals | Alpaca_ HOOK2 ( ortholog_one2one ) Dog_ HOOK2 ( ortholog_one2one ) GuineaPig_ HOOK2 ( ortholog_one2one ) Macaque_ HOOK2 ( ortholog_one2one ) Mouse_ Hook2 ( ortholog_one2one ) Pig_ HOOK2 ( ortholog_one2one ) Rat_ Hook2 ( ortholog_one2one ) |
| Ohnologs | HOOK1 |
| Paralogs | HOOK3, HOOK1, CCDC88A, CCDC88B, CCDC88C |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2305376 rs897804 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17140400}. Cytoplasm {ECO:0000269|PubMed:32073997}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7TMK6}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:32073997}. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome (PubMed:17540036). Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (PubMed:17540036, PubMed:32073997). Often found in close association with microtubules (PubMed:17540036). Localizes to the manchette in elongating spermatids (By similarity). {ECO:0000250|UniProtKB:Q7TMK6, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:32073997}. |
| Mouse PG classification | NA |
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