| Gene Information | |
|---|---|
| Gene Name | HOOK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 728 |
| Protein Names | Protein Hook homolog 1 (h-hook1) (hHK1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000134709 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q9UJC3 |
| Gene Card | HOOK1 |
| Uniprot ID | Q9UJC3 |
| Pfam | PF05622; PF19047 |
| In ASD | no |
| Allosteric Prediction | no (-1.450040243) |
| Ortholog in Animals | Alpaca_ HOOK1 ( ortholog_one2one ) Dog_ HOOK1 ( ortholog_one2one ) GuineaPig_ HOOK1 ( ortholog_one2one ) Macaque_ HOOK1 ( ortholog_one2one ) Mouse_ Hook1 ( ortholog_one2one ) Rat_ Hook1 ( ortholog_one2one ) Rabbit_ HOOK1 ( ortholog_one2one ) |
| Ohnologs | HOOK2, HOOK3 |
| Paralogs | HOOK3, CCDC88A, CCDC88B, CCDC88C, HOOK2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1008809819 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15471887}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11238449}. Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria (By similarity). Often found in close association with microtubules (By similarity). Does not associate with the Golgi complex. During spermiogenesis, it localizes to the manchette in spermatids from steps 8-10. It is also present between the microtubule manchette and the nucleus. During manchette elongation, it is preferentially localized to the nuclear ring of the manchette, whereas the strong localization to the manchette decreases. In more mature spermatids, while the manchette migrates posteriorly, it localizes to punctuates spots. At later stages of spermatid differentiation, the punctuate expression pattern is found at both the attachment site and the proximal end of the elongated manchette. In contrast, it is not present in mature spermatozoa (By similarity). {ECO:0000250|UniProtKB:Q8BIL5}. |
| Mouse PG classification | NA |
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