| Gene Information | |
|---|---|
| Gene Name | CDK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 297 |
| Protein Names | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) |
| Target Name | cyclin-dependent kinase 1 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000170312 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P06493 |
| Gene Card | CDK1 |
| Uniprot ID | P06493 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.971764035) |
| Ortholog in Animals | Alpaca_ CDK1 ( ortholog_one2one ) Dog_ CDK1 ( ortholog_one2one ) Macaque_ CDK1 ( ortholog_one2one ) Mouse_ Cdk1 ( ortholog_one2one ) Pig_ CDK1 ( ortholog_one2one ) Rat_ Cdk1 ( ortholog_one2one ) Rabbit_ CDK1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CDK14, CDKL2, CDK5, CDKL3, CDK7, CDKL1, CDK19, CDKL5, CDK6, CDK16, CDK15, CDK4, CDKL4, CDK2, CDK20, CDK9, CDK12, CDK8, CDK10, CDK11B, CDK11A, CDK13, CDK18, CDK17, PRPF4B, CDK3 |
| Tissue | brain, lung, spleen, testis |
| Tissue Specificity | Isoform 2 is found in breast cancer tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.040426(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4Y72 (X-ray 2.30A ) 4YC3 (X-ray 2.70A ) 4YC6 (X-ray 2.60A ) 5HQ0 (X-ray 2.30A ) 5LQF (X-ray 2.06A ) 6GU2 (X-ray 2.00A ) 6GU3 (X-ray 2.65A ) 6GU4 (X-ray 2.73A ) 6GU6 (X-ray 2.33A ) 6GU7 (X-ray 2.75A ) 6TWN (X-ray 2.28A ) 7NJ0 (EM 3.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:P11440}. Cytoplasm {ECO:0000250|UniProtKB:P11440}. Mitochondrion {ECO:0000269|PubMed:19917720}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage. |
| Mouse PG classification | NA |
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