| Gene Information | |
|---|---|
| Gene Name | H731 |
| Organism | Homo sapiens (Human) |
| Gene Length | 469 |
| Protein Names | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q53EL6 |
| Gene Card | PDCD4 |
| Uniprot ID | Q53EL6 |
| Pfam | PF02847 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. {ECO:0000269|PubMed:10632927, ECO:0000269|PubMed:12898601, ECO:0000269|PubMed:16449643}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2GGF (NMR - ) 2KZT (NMR - ) 2RG8 (X-ray 1.80A ) 2ZU6 (X-ray 2.80A ) 3EIJ (X-ray 2.80A ) |
| DBSNP | rs7081726 rs11548765 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q61823}. Cytoplasm {ECO:0000250|UniProtKB:Q61823}. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). {ECO:0000269|PubMed:16357133}. |
| Mouse PG classification | NA |
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