| Gene Information | |
|---|---|
| Gene Name | OPRK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 380 |
| Protein Names | Kappa-type opioid receptor (K-OR-1) (KOR-1) |
| Target Name | kappa-type opioid receptor |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000082556 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P41145 |
| Gene Card | OPRK1 |
| Uniprot ID | P41145 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.31966949) |
| Ortholog in Animals | Alpaca_ OPRK1 ( ortholog_one2one ) Dog_ OPRK1 ( ortholog_one2one ) GuineaPig_ OPRK1 ( ortholog_one2one ) Macaque_ OPRK1 ( ortholog_one2one ) Mouse_ Oprk1 ( ortholog_one2one ) Pig_ OPRK1 ( ortholog_one2one ) Rat_ Oprk1 ( ortholog_one2one ) Rabbit_ OPRK1 ( ortholog_one2one ) |
| Ohnologs | OPRL1, NPBWR2, SSTR4, OPRM1, OPRD1 |
| Paralogs | SSTR5, SSTR4, NPBWR1, OPRL1, GPR149, OPRM1, PTGDR2, SSTR3, CMKLR2, SSTR1, LTB4R, LTB4R2, KISS1R, UTS2R, NPBWR2, SSTR2, OPRD1 |
| Tissue | NA |
| Tissue Specificity | Detected in brain and placenta. {ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4DJH (X-ray 2.90A ) 6B73 (X-ray 3.10A ) 6VI4 (X-ray 3.30A ) 7T10 (EM 2.50A ) 7T11 (EM 2.70A ) 7UL2 (EM 2.40A ) 7UL5 (EM 3.10A ) |
| DBSNP | rs9282808 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}. |
| Mouse PG classification | NA |
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