| Gene Information | |
|---|---|
| Gene Name | SERPIND1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 499 |
| Protein Names | Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1) |
| Target Name | heparin cofactor 2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000099937 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P05546 |
| Gene Card | SERPIND1 |
| Uniprot ID | P05546 |
| Pfam | PF00079 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000126831) |
| Ortholog in Animals | Alpaca_ SERPIND1 ( ortholog_one2one ) Dog_ SERPIND1 ( ortholog_one2one ) GuineaPig_ SERPIND1 ( ortholog_one2one ) Macaque_ SERPIND1 ( ortholog_one2one ) Mouse_ Serpind1 ( ortholog_one2one ) Pig_ SERPIND1 ( ortholog_one2one ) Rat_ Serpind1 ( ortholog_one2one ) Rabbit_ SERPIND1 ( ortholog_one2one ) |
| Ohnologs | SERPINA10, SERPINA12, SERPINA9, SERPINA5, SERPINA3 |
| Paralogs | SERPING1, SERPINB7, SERPINF1, SERPINI1, AGT, SERPINA7, SERPINB8, SERPINA6, SERPINI2, HMSD, SERPINB6, SERPINC1, SERPINB1, SERPINA10, SERPINH1, SERPINB13, SERPINA3, SERPINA5, SERPINA9, SERPINA12, SERPINE1, SERPINF2, SERPINA4, SERPINB11, SERPINB5, SERPINB12, SERPINB9, SERPINE3, SERPINB4, SERPINB3, SERPINE2, SERPINA1, SERPINA2, SERPINB10, SERPINA11, SERPINB2 |
| Tissue | liver |
| Tissue Specificity | Expressed predominantly in liver. Also present in plasma. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JMJ (X-ray 2.35A ) 1JMO (X-ray 2.20A ) 2NAT (NMR - ) 2NCU (NMR - ) 2NCV (NMR - ) 2NCW (NMR - ) 6J12 (NMR - ) 6KBO (NMR - ) 6KBV (NMR - ) |
| DBSNP | rs5905 rs165867 rs34324685 rs11542069 rs5907 rs1042435 rs5904 rs142451096 rs121912420 |
| Subcellular location [CC] | NA |
| Mouse PG classification | HPG |
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