| Gene Information | |
|---|---|
| Gene Name | GDAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 358 |
| Protein Names | Ganglioside-induced differentiation-associated protein 1 (GDAP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000104381 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TB36 |
| Gene Card | GDAP1 |
| Uniprot ID | Q8TB36 |
| Pfam | PF13417 |
| In ASD | yes |
| Allosteric Prediction | no (-1.203770517) |
| Ortholog in Animals | Alpaca_ GDAP1 ( ortholog_one2one ) Dog_ GDAP1 ( ortholog_one2one ) GuineaPig_ GDAP1 ( ortholog_one2one ) Macaque_ GDAP1 ( ortholog_one2one ) Mouse_ Gdap1 ( ortholog_one2one ) Pig_ GDAP1 ( ortholog_one2one ) Rat_ Gdap1 ( ortholog_one2one ) Rabbit_ GDAP1 ( ortholog_one2one ) |
| Ohnologs | GDAP1L1 |
| Paralogs | CLIC2, GSTZ1, GSTO2, GDAP1L1, CLIC3, GSTT4, CLIC4, GSTT2, GSTT2B, CLIC1, EEF1G, GSTO1, CLIC6, CLIC5 |
| Tissue | cerebellum, putamen, substantia.nigra |
| Tissue Specificity | Highly expressed in whole brain and spinal cord. Predominant expression in central tissues of the nervous system not only in neurons but also in Schwann cells. {ECO:0000269|PubMed:11743580, ECO:0000269|PubMed:16172208}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7AIA (X-ray 2.20A ) 7ALM (X-ray 2.80A ) 7B2G (X-ray 3.00A ) 7Q6J (X-ray 2.20A ) 7Q6K (X-ray 3.41A ) 7YWD (X-ray 3.20A ) |
| DBSNP | rs1586794314 rs104894078 rs1174933176 rs104894078 rs397515442 rs879254005 rs397515441 rs104894076 rs121908113 rs267606842 rs1586807209 rs1476856429 rs28937906 rs375431837 rs1323153568 rs538389475 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:15772096, ECO:0000269|PubMed:16172208, ECO:0000269|PubMed:16857173}; Multi-pass membrane protein {ECO:0000269|PubMed:16172208}. Cytoplasm {ECO:0000250|UniProtKB:O88741}. |
| Mouse PG classification | HPG |
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