| Gene Information | |
|---|---|
| Gene Name | HMGCS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 520 |
| Protein Names | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) |
| Target Name | hydroxymethylglutaryl-coa synthase, cytoplasmic |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000112972 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q01581 |
| Gene Card | HMGCS1 |
| Uniprot ID | Q01581 |
| Pfam | PF08540; PF01154 |
| In ASD | no |
| Allosteric Prediction | yes (0.74526038) |
| Ortholog in Animals | Alpaca_ HMGCS1 ( ortholog_one2one ) Dog_ HMGCS1 ( ortholog_one2one ) GuineaPig_ HMGCS1 ( ortholog_one2one ) Macaque_ HMGCS1 ( ortholog_one2one ) Mouse_ Hmgcs1 ( ortholog_one2one ) Pig_ HMGCS1 ( ortholog_one2one ) Rat_ Hmgcs1 ( ortholog_one2one ) Rabbit_ HMGCS1 ( ortholog_one2one ) |
| Ohnologs | HMGCS2 |
| Paralogs | HMGCS2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.050380(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2P8U (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000305|PubMed:1358203}. |
| Mouse PG classification | NA |
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