Gene Information
Gene NamePODXL
OrganismHomo sapiens (Human)
Gene Length558
Protein NamesPodocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000128567 )
Evolutionary StageVertebrata
AlphaFoldDBO00592
Gene CardPODXL
Uniprot IDO00592
PfamPF06365
In ASDno
Allosteric Predictionno (-0.30482235)
Ortholog in AnimalsAlpaca_ PODXL ( ortholog_one2one )
Dog_ PODXL ( ortholog_one2one )
Macaque_ PODXL ( ortholog_one2one )
Mouse_ Podxl ( ortholog_one2one )
Rat_ Podxl ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityGlomerular epithelium cell (podocyte).
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs3735035  rs55698400  rs12670788  rs35893129  rs3212298 
Subcellular location [CC]Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus {ECO:0000250}. Membrane raft {ECO:0000250}. Membrane {ECO:0000305};
Single-pass type I membrane protein {ECO:0000305}. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells. Colocalizes with ITGB1. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis (By similarity). {ECO:0000250}.
Mouse PG classificationNA
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