| Gene Information | |
|---|---|
| Gene Name | DKK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 266 |
| Protein Names | Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK) |
| Target Name | dickkopf-related protein 1 |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000107984 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O94907 |
| Gene Card | DKK1 |
| Uniprot ID | O94907 |
| Pfam | PF04706 |
| In ASD | no |
| Allosteric Prediction | yes (0.170025215) |
| Ortholog in Animals | Alpaca_ DKK1 ( ortholog_one2one ) Dog_ DKK1 ( ortholog_one2one ) GuineaPig_ DKK1 ( ortholog_one2one ) Macaque_ DKK1 ( ortholog_one2one ) Mouse_ Dkk1 ( ortholog_one2one ) Pig_ DKK1 ( ortholog_one2one ) Rat_ NEWGENE_1307313 ( ortholog_one2one ) Rabbit_ DKK1 ( ortholog_one2one ) |
| Ohnologs | DKK4, DKK2 |
| Paralogs | NA |
| Tissue | placenta |
| Tissue Specificity | Placenta. |
| Pharmacological Animal Models | 0.039269(Chimpanzee);0.054496(Mouse);0.001000(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3S2K (X-ray 2.80A ) 3S8V (X-ray 3.10A ) 3SOQ (X-ray 1.90A ) 5FWW (X-ray 3.50A ) 5GJE (EM 21.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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