| Gene Information | |
|---|---|
| Gene Name | UVRAG |
| Organism | Homo sapiens (Human) |
| Gene Length | 699 |
| Protein Names | UV radiation resistance-associated gene protein (p63) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000198382 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9P2Y5 |
| Gene Card | UVRAG |
| Uniprot ID | Q9P2Y5 |
| Pfam | PF10186 |
| In ASD | no |
| Allosteric Prediction | yes (0.108263056) |
| Ortholog in Animals | Alpaca_ UVRAG ( ortholog_one2one ) Dog_ UVRAG ( ortholog_one2one ) GuineaPig_ UVRAG ( ortholog_one2one ) Macaque_ UVRAG ( ortholog_one2one ) Mouse_ Uvrag ( ortholog_one2one ) Pig_ UVRAG ( ortholog_one2one ) Rat_ Uvrag ( ortholog_one2one ) Rabbit_ UVRAG ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain, lung, kidney and liver. {ECO:0000269|PubMed:10798355}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001390(Rat);0.016(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7BL1 (EM 9.80A ) |
| DBSNP | rs7118567 |
| Subcellular location [CC] | Late endosome {ECO:0000269|PubMed:18843052}. Lysosome {ECO:0000269|PubMed:18843052}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:28306502}. Early endosome {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:18843052}. Endoplasmic reticulum {ECO:0000269|PubMed:24056303}. Midbody {ECO:0000269|PubMed:20643123}. Chromosome, centromere {ECO:0000269|PubMed:22542840}. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial (PubMed:24056303). Recruited to autophagosome following interaction with RUBCNL/PACER (PubMed:28306502). {ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502}. |
| Mouse PG classification | NA |
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