| Gene Information | |
|---|---|
| Gene Name | SLCO3A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 710 |
| Protein Names | Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (Organic anion-transporting polypeptide D) (OATP-D) (PGE1 transporter) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11) |
| Target Name | organic anion transporter d |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000176463 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UIG8 |
| Gene Card | SLCO3A1 |
| Uniprot ID | Q9UIG8 |
| Pfam | PF07648; PF03137 |
| In ASD | no |
| Allosteric Prediction | no (-0.241134143) |
| Ortholog in Animals | Alpaca_ SLCO3A1 ( ortholog_one2one ) Dog_ SLCO3A1 ( ortholog_one2one ) GuineaPig_ SLCO3A1 ( ortholog_one2one ) Macaque_ SLCO3A1 ( ortholog_one2one ) Mouse_ Slco3a1 ( ortholog_one2one ) Pig_ SLCO3A1 ( ortholog_one2one ) Rat_ Slco3a1 ( ortholog_one2one ) Rabbit_ SLCO3A1 ( ortholog_one2one ) |
| Ohnologs | SLCO1A2, SLCO1C1 |
| Paralogs | SLCO5A1, SLCO6A1, SLCO4C1, SLCO4A1, SLCO2B1, SLCO1B1, SLCO1B3, SLCO1C1, SLCO1A2, SLCO2A1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex. Expressed in placental trophoblasts (PubMed:10873595, PubMed:12409283). Expressed in pancreas, kidney, liver, lung, brain, heart, peripheral blood leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and pancreas (PubMed:10873595). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:16971491}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1517618 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
| click here to return to the previous page | |