| Gene Information | |
|---|---|
| Gene Name | HM13 |
| Organism | Homo sapiens (Human) |
| Gene Length | 377 |
| Protein Names | Minor histocompatibility antigen H13 (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase) |
| Target Name | minor histocompatibility antigen h13 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000101294 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TCT9 |
| Gene Card | HM13 |
| Uniprot ID | Q8TCT9 |
| Pfam | PF04258 |
| In ASD | no |
| Allosteric Prediction | no (-0.479955874) |
| Ortholog in Animals | Dog_ HM13 ( ortholog_one2one ) GuineaPig_ HM13 ( ortholog_one2one ) Macaque_ HM13 ( ortholog_one2one ) Mouse_ H13 ( ortholog_one2one ) Pig_ HM13 ( ortholog_one2one ) Rat_ Hm13 ( ortholog_one2one ) Rabbit_ HM13 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SPPL2B, SPPL3, SPPL2C, SPPL2A |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla. {ECO:0000269|PubMed:12139484, ECO:0000269|PubMed:12972007}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1044419 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:15385547}.; [Isoform 4]: Cell membrane {ECO:0000250|UniProtKB:Q9D8V0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9D8V0}. |
| Mouse PG classification | NA |
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