Gene Information
Gene NameHLTF
OrganismHomo sapiens (Human)
Gene Length1009
Protein NamesHelicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000071794 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ14527
Gene CardHLTF
Uniprot IDQ14527
PfamPF00271; PF08797; PF00176
In ASDno
Allosteric Predictionno (-0.587514436)
Ortholog in AnimalsAlpaca_ HLTF ( ortholog_one2one )
Dog_ HLTF ( ortholog_one2one )
GuineaPig_ HLTF ( ortholog_one2one )
Macaque_ HLTF ( ortholog_one2one )
Mouse_ Hltf ( ortholog_one2one )
Pig_ HLTF ( ortholog_one2one )
Rat_ Hltf ( ortholog_one2one )
Rabbit_ HLTF ( ortholog_one2one )
OhnologsNA
ParalogsSMARCA1, RAD54B, HELLS, SHPRH, BTAF1, ZRANB3, SMARCA5, TTF2, SMARCA2, CHD9, SMARCAL1, CHD1L, CHD3, RAD54L2, SMARCAD1, CHD4, ATRX, INO80, CHD6, SRCAP, CHD1, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6, ERCC6L, CHD5, SMARCA4
TissueNA
Tissue SpecificityExpressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2MZN  (NMR  -  )  4HRE  (X-ray  2.79A  )  4HRH  (X-ray  3.00A  )  4S0N  (X-ray  1.50A  )  4XZF  (X-ray  1.38A  )  4XZG  (X-ray  2.40A  )  5BNH  (X-ray  1.70A  )  5K5F  (NMR  -  )  6KCS  (X-ray  2.10A  ) 
DBSNP rs2305868  rs2228257  rs2229361 
Subcellular location [CC]Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:8672239}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Nuclear localization is stimulated by progesterone. {ECO:0000250}.
Mouse PG classificationNA
click here to return to the previous page