| Gene Information | |
|---|---|
| Gene Name | HLCS |
| Organism | Homo sapiens (Human) |
| Gene Length | 726 |
| Protein Names | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] |
| Target Name | biotin--protein ligase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000159267 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P50747 |
| Gene Card | HLCS |
| Uniprot ID | P50747 |
| Pfam | PF02237; PF03099 |
| In ASD | no |
| Allosteric Prediction | no (-0.160491853) |
| Ortholog in Animals | Alpaca_ HLCS ( ortholog_one2one ) Dog_ HLCS ( ortholog_one2one ) GuineaPig_ HLCS ( ortholog_one2one ) Macaque_ HLCS ( ortholog_one2one ) Mouse_ Hlcs ( ortholog_one2one ) Pig_ HLCS ( ortholog_one2one ) Rat_ Hlcs ( ortholog_one2one ) Rabbit_ HLCS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:7842009, PubMed:7753853). Mostly expressed in muscle, placenta and to a lower extent in the brain, kidney, pancreas, liver and lung (PubMed:7842009). {ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs61732504 rs28934602 rs119103227 rs1198548955 rs1230666123 rs769499327 rs781603756 rs1256356959 rs1261821166 rs1555885056 rs119103229 rs119103231 rs119103228 rs119103230 rs376899782 rs149399432 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305|PubMed:7842009}. Mitochondrion {ECO:0000305|PubMed:7842009}. |
| Mouse PG classification | NA |
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