| Gene Information | |
|---|---|
| Gene Name | CYB5R3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 301 |
| Protein Names | NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1) |
| Target Name | nadh-cytochrome b5 reductase 3 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000100243 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P00387 |
| Gene Card | CYB5R3 |
| Uniprot ID | P00387 |
| Pfam | PF00970; PF00175 |
| In ASD | no |
| Allosteric Prediction | yes (0.340855645) |
| Ortholog in Animals | Alpaca_ CYB5R3 ( ortholog_one2one ) Dog_ CYB5R3 ( ortholog_one2one ) GuineaPig_ CYB5R3 ( ortholog_one2one ) Macaque_ CYB5R3 ( ortholog_one2one ) Mouse_ Cyb5r3 ( ortholog_one2one ) Pig_ CYB5R3 ( ortholog_one2one ) Rat_ Cyb5r3 ( ortholog_one2one ) Rabbit_ CYB5R3 ( ortholog_one2one ) |
| Ohnologs | CYB5R1, CYB5R2 |
| Paralogs | CYB5RL, CYB5R1, CYB5R4, OXNAD1, CYB5R2 |
| Tissue | NA |
| Tissue Specificity | [Isoform 2]: Expressed at late stages of erythroid maturation. {ECO:0000269|PubMed:9639531}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1UMK (X-ray 1.75A ) |
| DBSNP | rs121965007 rs1130706 rs121965013 rs121965009 rs1800457 rs121965006 rs121965008 rs201232518 rs121965011 rs121965015 rs121965017 rs794728012 rs121965016 rs121965012 |
| Subcellular location [CC] | [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9639531}; Lipid-anchor {ECO:0000250|UniProtKB:P20070}; Cytoplasmic side {ECO:0000250|UniProtKB:P20070}. Mitochondrion outer membrane {ECO:0000305|PubMed:9639531}; Lipid-anchor {ECO:0000250|UniProtKB:P20070}; Cytoplasmic side {ECO:0000250|UniProtKB:P20070}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:9639531}. |
| Mouse PG classification | NA |
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