Gene Information
Gene NameHLA-G
OrganismHomo sapiens (Human)
Gene Length338
Protein NamesHLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)]
Target Namemhc class i antigen g
Target TypeClinical trial target
Gene Age12 ( ENSG00000204632 )
3 ( ENSG00000206506 )
3 ( ENSG00000230413 )
3 ( ENSG00000233095 )
3 ( ENSG00000235346 )
3 ( ENSG00000235680 )
3 ( ENSG00000237216 )
3 ( ENSG00000276051 )
Evolutionary StageVertebrata
AlphaFoldDBP17693
Gene CardHLA-G
Uniprot IDP17693
PfamPF07654; PF00129
In ASDno
Allosteric Predictionno (-0.196220974)
Ortholog in AnimalsAlpaca_ PATR-G ( ortholog_one2one )
Mouse_ H2-M10.6 ( ortholog_many2many )
Mouse_ H2-M10.4 ( ortholog_many2many )
Mouse_ H2-M1 ( ortholog_many2many )
Mouse_ H2-D1 ( ortholog_many2many )
Mouse_ H2-Q1 ( ortholog_many2many )
Mouse_ H2-T3 ( ortholog_many2many )
Mouse_ H2-Q2 ( ortholog_many2many )
Mouse_ H2-Q4 ( ortholog_many2many )
Mouse_ Gm8909 ( ortholog_many2many )
Mouse_ H2-Q7 ( ortholog_many2many )
Mouse_ H2-M11 ( ortholog_many2many )
Mouse_ H2-Q10 ( ortholog_many2many )
Mouse_ H2-M10.1 ( ortholog_many2many )
Mouse_ Gm11127 ( ortholog_many2many )
Mouse_ H2-M9 ( ortholog_many2many )
Mouse_ H2-T23 ( ortholog_many2many )
Mouse_ H2-M5 ( ortholog_many2many )
Mouse_ H2-M3 ( ortholog_many2many )
Mouse_ H2-M10.3 ( ortholog_many2many )
Mouse_ H2-M10.2 ( ortholog_many2many )
Mouse_ H2-Q6 ( ortholog_many2many )
Mouse_ H2-T22 ( ortholog_many2many )
Mouse_ H2-M10.5 ( ortholog_many2many )
Mouse_ Gm7030 ( ortholog_many2many )
Mouse_ H2-T10 ( ortholog_many2many )
Mouse_ H2-M2 ( ortholog_many2many )
Mouse_ 2410137M14Rik ( ortholog_many2many )
Mouse_ H2-K1 ( ortholog_many2many )
Rat_ AABR07072807.1 ( ortholog_many2many )
Rat_ RT1-S2 ( ortholog_many2many )
Rat_ RT1-M1-4 ( ortholog_many2many )
Rat_ RT1-CE16 ( ortholog_many2many )
Rat_ RT1-S3 ( ortholog_many2many )
Rat_ AABR07044308.2 ( ortholog_many2many )
Rat_ RT1-M1-2 ( ortholog_many2many )
Rat_ AABR07044383.1 ( ortholog_many2many )
Rat_ AABR07044308.1 ( ortholog_many2many )
Rat_ RT1-M3-1 ( ortholog_many2many )
Rat_ RT1-CE14 ( ortholog_many2many )
Rat_ RT1-CE11 ( ortholog_many2many )
Rat_ RT1-N3 ( ortholog_many2many )
Rat_ RT1-CE2 ( ortholog_many2many )
Rat_ RT1-CE1 ( ortholog_many2many )
Rat_ AABR07044397.1 ( ortholog_many2many )
Rat_ AABR07044362.1 ( ortholog_many2many )
Rat_ RT1-M2 ( ortholog_many2many )
Rat_ RT1-M6-2 ( ortholog_many2many )
Rat_ RT1-M5 ( ortholog_many2many )
Rat_ RT1-M10-1 ( ortholog_many2many )
Rat_ RT1-N2 ( ortholog_many2many )
OhnologsNA
ParalogsMR1, AZGP1, MICA, HFE, MICB, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, CD1A, CD1D, CD1C, RAET1E, ULBP3, ULBP1, CD1E, HLA-B, HLA-A, HLA-C, HLA-F, HLA-E
Tissueplacenta
Tissue SpecificityExpressed in adult eye (PubMed:1570318). Expressed in immune cell subsets including monocytes, myeloid and plasmacytoid dendritic cells and regulatory T cells (Tr1)(at protein level) (PubMed:20448110). Secreted by follicular dendritic cell and follicular helper T cells (PubMed:24453251).;
[Isoform 5]: Detected in physiological fluids including amniotic fluid and serum. {ECO:0000269|PubMed:11137219}.;
[Isoform 7]: Expressed in placenta, amniotic membrane, skin, cord blood and peripheral blood mononuclear cells. {ECO:0000269|PubMed:11137219}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1YDP  (X-ray  1.90A  )  2D31  (X-ray  3.20A  )  2DYP  (X-ray  2.50A  )  3BZE  (X-ray  2.50A  )  3CDG  (X-ray  3.40A  )  3CII  (X-ray  4.41A  )  3KYN  (X-ray  2.40A  )  3KYO  (X-ray  1.70A  )  6AEE  (X-ray  3.30A  )  6K60  (X-ray  3.15A  ) 
DBSNP NA 
Subcellular location [CC][Isoform 1]: Cell membrane {ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:7584149};
Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11520457}. Early endosome membrane {ECO:0000269|PubMed:16366734}.;
[Soluble HLA class I histocompatibility antigen, alpha chain G]: Secreted {ECO:0000269|PubMed:23737137}.;
[Isoform 2]: Cell membrane {ECO:0000269|PubMed:11290782};
Single-pass type I membrane protein {ECO:0000255}.;
[Isoform 3]: Cell membrane {ECO:0000269|PubMed:11290782};
Single-pass type I membrane protein {ECO:0000255}.;
[Isoform 4]: Cell membrane {ECO:0000269|PubMed:11290782};
Single-pass type I membrane protein {ECO:0000255}.;
[Isoform 5]: Secreted {ECO:0000269|PubMed:11137219, ECO:0000269|PubMed:7558941, ECO:0000269|PubMed:7584149, ECO:0000269|PubMed:7989753}. Early endosome {ECO:0000269|PubMed:16366734}.;
[Isoform 6]: Secreted {ECO:0000269|PubMed:7989753}.;
[Isoform 7]: Secreted {ECO:0000269|PubMed:11137219}.;
Cell projection, filopodium membrane {ECO:0000269|PubMed:26460007}. Note=HLA-G trogocytosis from extravillous trophoblast's filopodia occurs in the majority of decidual NK cells. {ECO:0000269|PubMed:26460007}.
Mouse PG classificationNA
click here to return to the previous page