| Gene Information | |
|---|---|
| Gene Name | PITX3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 302 |
| Protein Names | Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000107859 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O75364 |
| Gene Card | PITX3 |
| Uniprot ID | O75364 |
| Pfam | PF00046; PF03826 |
| In ASD | no |
| Allosteric Prediction | no (-1.087791534) |
| Ortholog in Animals | Alpaca_ PITX3 ( ortholog_one2one ) Dog_ PITX3 ( ortholog_one2one ) GuineaPig_ PITX3 ( ortholog_one2one ) Macaque_ PITX3 ( ortholog_one2one ) Mouse_ Pitx3 ( ortholog_one2one ) Pig_ PITX3 ( ortholog_one2one ) Rat_ Pitx3 ( ortholog_one2one ) Rabbit_ PITX3 ( ortholog_one2one ) |
| Ohnologs | PITX1, PITX2 |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PRRX1, SHOX, SHOX2, PRRX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in developing eye lens. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs104894175 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}. |
| Mouse PG classification | HPG |
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