| Gene Information | |
|---|---|
| Gene Name | HLA-F |
| Organism | Homo sapiens (Human) |
| Gene Length | 346 |
| Protein Names | HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000137403 ) 382 ( ENSG00000204642 ) 3 ( ENSG00000206509 ) 3 ( ENSG00000229698 ) 3 ( ENSG00000234487 ) 3 ( ENSG00000235220 ) 3 ( ENSG00000237508 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P30511 |
| Gene Card | HLA-F |
| Uniprot ID | P30511 |
| Pfam | PF07654; PF00129 |
| In ASD | no |
| Allosteric Prediction | no (-0.722394309) |
| Ortholog in Animals | Alpaca_ PATR-F ( ortholog_one2one ) Dog_ DLA-79 ( ortholog_one2one ) Macaque_ HLA-F ( ortholog_one2one ) Mouse_ H2-M10.6 ( ortholog_many2many ) Mouse_ H2-M10.4 ( ortholog_many2many ) Mouse_ H2-M1 ( ortholog_many2many ) Mouse_ H2-D1 ( ortholog_many2many ) Mouse_ H2-Q1 ( ortholog_many2many ) Mouse_ H2-T3 ( ortholog_many2many ) Mouse_ H2-Q2 ( ortholog_many2many ) Mouse_ H2-Q4 ( ortholog_many2many ) Mouse_ Gm8909 ( ortholog_many2many ) Mouse_ H2-Q7 ( ortholog_many2many ) Mouse_ H2-M11 ( ortholog_many2many ) Mouse_ H2-Q10 ( ortholog_many2many ) Mouse_ H2-M10.1 ( ortholog_many2many ) Mouse_ Gm11127 ( ortholog_many2many ) Mouse_ H2-M9 ( ortholog_many2many ) Mouse_ H2-T23 ( ortholog_many2many ) Mouse_ H2-M5 ( ortholog_many2many ) Mouse_ H2-M3 ( ortholog_many2many ) Mouse_ H2-M10.3 ( ortholog_many2many ) Mouse_ H2-M10.2 ( ortholog_many2many ) Mouse_ H2-Q6 ( ortholog_many2many ) Mouse_ H2-T22 ( ortholog_many2many ) Mouse_ H2-M10.5 ( ortholog_many2many ) Mouse_ Gm7030 ( ortholog_many2many ) Mouse_ H2-T10 ( ortholog_many2many ) Mouse_ H2-M2 ( ortholog_many2many ) Mouse_ 2410137M14Rik ( ortholog_many2many ) Mouse_ H2-K1 ( ortholog_many2many ) Rat_ AABR07072807.1 ( ortholog_many2many ) Rat_ RT1-S2 ( ortholog_many2many ) Rat_ RT1-M1-4 ( ortholog_many2many ) Rat_ RT1-CE16 ( ortholog_many2many ) Rat_ RT1-S3 ( ortholog_many2many ) Rat_ AABR07044308.2 ( ortholog_many2many ) Rat_ RT1-M1-2 ( ortholog_many2many ) Rat_ AABR07044383.1 ( ortholog_many2many ) Rat_ AABR07044308.1 ( ortholog_many2many ) Rat_ RT1-M3-1 ( ortholog_many2many ) Rat_ RT1-CE14 ( ortholog_many2many ) Rat_ RT1-CE11 ( ortholog_many2many ) Rat_ RT1-N3 ( ortholog_many2many ) Rat_ RT1-CE2 ( ortholog_many2many ) Rat_ RT1-CE1 ( ortholog_many2many ) Rat_ AABR07044397.1 ( ortholog_many2many ) Rat_ AABR07044362.1 ( ortholog_many2many ) Rat_ RT1-M2 ( ortholog_many2many ) Rat_ RT1-M6-2 ( ortholog_many2many ) Rat_ RT1-M5 ( ortholog_many2many ) Rat_ RT1-M10-1 ( ortholog_many2many ) Rat_ RT1-N2 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | MR1, AZGP1, MICA, HFE, MICB, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, CD1A, CD1D, CD1C, RAET1E, ULBP3, ULBP1, CD1E, HLA-B, HLA-A, HLA-G, HLA-C, HLA-E |
| Tissue | NA |
| Tissue Specificity | Expressed in resting B cells (at protein level). Expressed in secondary lymphoid organs rich in B and T cells such as the tonsils, spleen, and thymus (at protein level) (PubMed:10605026, PubMed:11169396). Expressed in the endothelial cells of the tonsils (PubMed:11169396). Expressed on activated lymphoid cells including B cells, NK cells, CD4+ T cells and memory T cells (at protein level) (PubMed:27455421, PubMed:20865824). Expressed in motor neurons of spinal cord (PubMed:26928464). {ECO:0000269|PubMed:10605026, ECO:0000269|PubMed:11169396, ECO:0000269|PubMed:20865824, ECO:0000269|PubMed:26928464, ECO:0000269|PubMed:27455421}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5IUE (X-ray 2.62A ) 5KNM (X-ray 3.30A ) |
| DBSNP | rs17875379 rs17875380 rs1736924 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16709803, ECO:0000269|PubMed:23851683, ECO:0000305|PubMed:27455421}; Single-pass type I membrane protein. Early endosome membrane {ECO:0000269|PubMed:23851683}. Lysosome membrane {ECO:0000269|PubMed:23851683}. Note=For cross-presentation transits from the cell surface through endosomal pathway to lysosomes, where the peptide is generated from internalized exogenous antigen. {ECO:0000269|PubMed:23851683}. |
| Mouse PG classification | NA |
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