| Gene Information | |
|---|---|
| Gene Name | EPHA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 983 |
| Protein Names | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) |
| Target Name | ephrin type-a receptor 3 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000044524 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P29320 |
| Gene Card | EPHA3 |
| Uniprot ID | P29320 |
| Pfam | PF14575; PF01404; PF07699; PF00041; PF07714; PF07647 |
| In ASD | yes |
| Allosteric Prediction | yes (0.587608114) |
| Ortholog in Animals | Alpaca_ EPHA3 ( ortholog_one2one ) Dog_ EPHA3 ( ortholog_one2one ) GuineaPig_ EPHA3 ( ortholog_one2one ) Macaque_ EPHA3 ( ortholog_one2one ) Mouse_ Epha3 ( ortholog_one2one ) Pig_ EPHA3 ( ortholog_one2one ) Rat_ Epha3 ( ortholog_one2one ) Rabbit_ EPHA3 ( ortholog_one2one ) |
| Ohnologs | EPHA7, EPHB4, EPHA8, EPHA4, EPHB2, EPHA2, EPHA10 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | prostate |
| Tissue Specificity | Widely expressed. Highest level in placenta. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2GSF (X-ray 1.77A ) 2QO2 (X-ray 1.60A ) 2QO7 (X-ray 1.60A ) 2QO9 (X-ray 1.55A ) 2QOB (X-ray 1.65A ) 2QOC (X-ray 1.25A ) 2QOD (X-ray 1.15A ) 2QOF (X-ray 1.20A ) 2QOI (X-ray 1.25A ) 2QOK (X-ray 1.20A ) 2QOL (X-ray 1.07A ) 2QON (X-ray 1.79A ) 2QOO (X-ray 1.25A ) 2QOQ (X-ray 1.60A ) 3DZQ (X-ray 1.75A ) 3FXX (X-ray 1.70A ) 3FY2 (X-ray 1.80A ) 4G2F (X-ray 1.70A ) 4GK2 (X-ray 2.20A ) 4GK3 (X-ray 1.90A ) 4GK4 (X-ray 2.10A ) 4L0P (X-ray 2.26A ) 4P4C (X-ray 1.60A ) 4P5Q (X-ray 1.35A ) 4P5Z (X-ray 2.00A ) 4TWN (X-ray 1.71A ) 4TWO (X-ray 2.05A ) 6IN0 (X-ray 1.50A ) |
| DBSNP | rs200567888 rs55712516 rs56077781 rs56081642 rs1414714315 rs34437982 rs17801309 rs35124509 rs372594677 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11870224}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:21135139}. |
| Mouse PG classification | NA |
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