| Gene Information | |
|---|---|
| Gene Name | HLA-DQA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 255 |
| Protein Names | HLA class II histocompatibility antigen, DQ alpha 2 chain (DX alpha chain) (HLA class II histocompatibility antigen, DQ(6) alpha chain) (HLA-DQA1) (MHC class II DQA2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000206301 ) 3 ( ENSG00000223793 ) 3 ( ENSG00000225103 ) 3 ( ENSG00000231526 ) 3 ( ENSG00000231823 ) 3 ( ENSG00000233192 ) 55 ( ENSG00000237541 ) 3 ( ENSG00000257473 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01906 |
| Gene Card | HLA-DQA2 |
| Uniprot ID | P01906 |
| Pfam | PF07654; PF00993 |
| In ASD | no |
| Allosteric Prediction | yes (0.067817092) |
| Ortholog in Animals | Alpaca_ HLA-DQA2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HLA-DPB1, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DRA, HLA-DRB5, HLA-DRB1, B2M, HLA-DQB1, HLA-DQB2, HLA-DMA, HLA-DQA1 |
| Tissue | NA |
| Tissue Specificity | Restricted to skin Langerhans cells, although some expression at low levels may occur at the surface of B lymphoblastoid cells. {ECO:0000269|PubMed:22407913, ECO:0000269|PubMed:9036956}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9276436 rs2071800 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Lysosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
| Mouse PG classification | NA |
| click here to return to the previous page | |