| Gene Information | |
|---|---|
| Gene Name | HLA-DOA |
| Organism | Homo sapiens (Human) |
| Gene Length | 250 |
| Protein Names | HLA class II histocompatibility antigen, DO alpha chain (MHC DN-alpha) (MHC DZ alpha) (MHC class II antigen DOA) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000204252 ) 3 ( ENSG00000206292 ) 3 ( ENSG00000230141 ) 3 ( ENSG00000231558 ) 3 ( ENSG00000232957 ) 3 ( ENSG00000232962 ) 3 ( ENSG00000235744 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P06340 |
| Gene Card | HLA-DOA |
| Uniprot ID | P06340 |
| Pfam | PF07654; PF00993 |
| In ASD | no |
| Allosteric Prediction | no (-0.385986048) |
| Ortholog in Animals | Alpaca_ HLA-DOA ( ortholog_one2one ) Dog_ DLA-DOA ( ortholog_one2one ) GuineaPig_ HLA-DOA ( ortholog_one2one ) Macaque_ HLA-DOA ( ortholog_one2one ) Mouse_ H2-Oa ( ortholog_one2one ) Pig_ SLA-DOA ( ortholog_one2one ) Rat_ RT1-DOa ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HLA-DPB1, HLA-DPA1, HLA-DMB, HLA-DQA1, HLA-DQA2, HLA-DOB, HLA-DRA, HLA-DRB5, HLA-DRB1, B2M, HLA-DQB1, HLA-DQB2, HLA-DMA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4I0P (X-ray 3.20A ) |
| DBSNP | rs41542323 rs11575906 |
| Subcellular location [CC] | Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER. |
| Mouse PG classification | NA |
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