| Gene Information | |
|---|---|
| Gene Name | HLA-DMB |
| Organism | Homo sapiens (Human) |
| Gene Length | 263 |
| Protein Names | HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB) (Really interesting new gene 7 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000226264 ) 3 ( ENSG00000234154 ) 3 ( ENSG00000239329 ) 3 ( ENSG00000241296 ) 3 ( ENSG00000241674 ) 3 ( ENSG00000242092 ) 3 ( ENSG00000242386 ) 382 ( ENSG00000242574 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P28068 |
| Gene Card | HLA-DMB |
| Uniprot ID | P28068 |
| Pfam | PF07654; PF00969 |
| In ASD | no |
| Allosteric Prediction | yes (0.003599762) |
| Ortholog in Animals | Alpaca_ PATR-DMB ( ortholog_one2one ) Dog_ DLA-DMB ( ortholog_one2one ) GuineaPig_ HLA-DMB ( ortholog_one2one ) Macaque_ HLA-DMB ( ortholog_one2one ) Mouse_ H2-DMb1 ( ortholog_one2many ) Mouse_ H2-DMb2 ( ortholog_one2many ) Pig_ SLA-DMB ( ortholog_one2one ) Rat_ RT1-DMb ( ortholog_one2one ) Rabbit_ HLA-DMB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HLA-DPB1, HLA-DPA1, HLA-DOA, HLA-DQA1, HLA-DQA2, HLA-DOB, HLA-DRA, HLA-DRB5, HLA-DRB1, B2M, HLA-DQB1, HLA-DQB2, HLA-DMA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HDM (X-ray 2.50A ) 2BC4 (X-ray 2.27A ) 4FQX (X-ray 2.60A ) 4GBX (X-ray 3.00A ) 4I0P (X-ray 3.20A ) |
| DBSNP | rs17583782 rs41560814 rs17617333 rs17617321 rs2071555 rs2071555 rs1042337 |
| Subcellular location [CC] | Late endosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Lysosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes. |
| Mouse PG classification | NA |
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