| Gene Information | |
|---|---|
| Gene Name | HLA-C |
| Organism | Homo sapiens (Human) |
| Gene Length | 366 |
| Protein Names | HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000204525 ) 3 ( ENSG00000206435 ) 3 ( ENSG00000206452 ) 3 ( ENSG00000225691 ) 3 ( ENSG00000228299 ) 3 ( ENSG00000233841 ) 3 ( ENSG00000237022 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P10321 |
| Gene Card | HLA-C |
| Uniprot ID | P10321 |
| Pfam | PF07654; PF00129; PF06623 |
| In ASD | no |
| Allosteric Prediction | no (-0.268071944) |
| Ortholog in Animals | Alpaca_ PATR-B ( ortholog_one2one ) Mouse_ H2-M10.6 ( ortholog_many2many ) Mouse_ H2-M10.4 ( ortholog_many2many ) Mouse_ H2-M1 ( ortholog_many2many ) Mouse_ H2-D1 ( ortholog_many2many ) Mouse_ H2-Q1 ( ortholog_many2many ) Mouse_ H2-T3 ( ortholog_many2many ) Mouse_ H2-Q2 ( ortholog_many2many ) Mouse_ H2-Q4 ( ortholog_many2many ) Mouse_ Gm8909 ( ortholog_many2many ) Mouse_ H2-Q7 ( ortholog_many2many ) Mouse_ H2-M11 ( ortholog_many2many ) Mouse_ H2-Q10 ( ortholog_many2many ) Mouse_ H2-M10.1 ( ortholog_many2many ) Mouse_ Gm11127 ( ortholog_many2many ) Mouse_ H2-M9 ( ortholog_many2many ) Mouse_ H2-T23 ( ortholog_many2many ) Mouse_ H2-M5 ( ortholog_many2many ) Mouse_ H2-M3 ( ortholog_many2many ) Mouse_ H2-M10.3 ( ortholog_many2many ) Mouse_ H2-M10.2 ( ortholog_many2many ) Mouse_ H2-Q6 ( ortholog_many2many ) Mouse_ H2-T22 ( ortholog_many2many ) Mouse_ H2-M10.5 ( ortholog_many2many ) Mouse_ Gm7030 ( ortholog_many2many ) Mouse_ H2-T10 ( ortholog_many2many ) Mouse_ H2-M2 ( ortholog_many2many ) Mouse_ 2410137M14Rik ( ortholog_many2many ) Mouse_ H2-K1 ( ortholog_many2many ) Rat_ AABR07072807.1 ( ortholog_many2many ) Rat_ RT1-S2 ( ortholog_many2many ) Rat_ RT1-M1-4 ( ortholog_many2many ) Rat_ RT1-CE16 ( ortholog_many2many ) Rat_ RT1-S3 ( ortholog_many2many ) Rat_ AABR07044308.2 ( ortholog_many2many ) Rat_ RT1-M1-2 ( ortholog_many2many ) Rat_ AABR07044383.1 ( ortholog_many2many ) Rat_ AABR07044308.1 ( ortholog_many2many ) Rat_ RT1-M3-1 ( ortholog_many2many ) Rat_ RT1-CE14 ( ortholog_many2many ) Rat_ RT1-CE11 ( ortholog_many2many ) Rat_ RT1-N3 ( ortholog_many2many ) Rat_ RT1-CE2 ( ortholog_many2many ) Rat_ RT1-CE1 ( ortholog_many2many ) Rat_ AABR07044397.1 ( ortholog_many2many ) Rat_ AABR07044362.1 ( ortholog_many2many ) Rat_ RT1-M2 ( ortholog_many2many ) Rat_ RT1-M6-2 ( ortholog_many2many ) Rat_ RT1-M5 ( ortholog_many2many ) Rat_ RT1-M10-1 ( ortholog_many2many ) Rat_ RT1-N2 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | MR1, AZGP1, MICA, HFE, MICB, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, CD1A, CD1D, CD1C, RAET1E, ULBP3, ULBP1, CD1E, HLA-B, HLA-A, HLA-G, HLA-F, HLA-E |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in fetal extravillous trophoblasts in the decidua basalis (at protein level). {ECO:0000269|PubMed:20972337}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EFX (X-ray 3.00A ) 1IM9 (X-ray 2.80A ) 1QQD (X-ray 2.70A ) 3BZF (X-ray 2.50A ) 4NT6 (X-ray 1.84A ) 5VGD (X-ray 2.32A ) 5VGE (X-ray 2.60A ) 5W67 (X-ray 2.30A ) 5W69 (X-ray 2.80A ) 5W6A (X-ray 1.74A ) 6JTO (X-ray 1.70A ) 6PA1 (X-ray 3.01A ) 6PAG (X-ray 2.50A ) |
| DBSNP | rs41548123 rs2308525 rs2308527 rs1050451 rs41549413 rs2074493 rs1131151 rs9264668 rs1050445 rs41542423 rs151341100 rs1050437 rs707911 rs1050428 rs1050409 rs28626310 rs41543814 rs2308557 rs17408553 rs1131123 rs1131119 rs1071649 rs1071649 rs1131118 rs1131115 rs1131115 rs1131115 rs34592426 rs2308574 rs2308575 rs713032 rs713032 rs142570222 rs1050366 rs2308590 rs41552817 rs2308592 rs2308592 rs796925732 rs2308598 rs1050357 rs1131103 rs1131096 rs1131096 rs1050343 rs1050716 rs41562012 rs1050328 rs1050276 rs707908 rs2308622 rs1131015 rs1211800658 rs2308628 rs41556321 rs1050180 rs1050147 rs146911342 rs1130947 rs1050105 rs1130935 rs41540416 rs3177824 rs1130838 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18420581, ECO:0000269|PubMed:20972337, ECO:0000269|PubMed:28649982}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:18420581}; Single-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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