Gene Information

Gene Information
Gene Name	HLA-A
Organism	Homo sapiens (Human)
Gene Length	365
Protein Names	HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Target Name	hla class i histocompatibility antigen, a-2 alpha chain
Target Type	NA
Gene Age	382 ( ENSG00000206503 ) 3 ( ENSG00000206505 ) 3 ( ENSG00000223980 ) 3 ( ENSG00000224320 ) 3 ( ENSG00000227715 ) 3 ( ENSG00000229215 ) 3 ( ENSG00000231834 ) 3 ( ENSG00000235657 )
Evolutionary Stage	Vertebrata
AlphaFoldDB	P04439
Gene Card	HLA-A
Uniprot ID	P04439
Pfam	PF07654; PF00129; PF06623
In ASD	no
Allosteric Prediction	yes (0.268730951)
Ortholog in Animals	Alpaca_ HLA-A ( ortholog_one2one ) Mouse_ H2-M10.6 ( ortholog_many2many ) Mouse_ H2-M10.4 ( ortholog_many2many ) Mouse_ H2-M1 ( ortholog_many2many ) Mouse_ H2-D1 ( ortholog_many2many ) Mouse_ H2-Q1 ( ortholog_many2many ) Mouse_ H2-T3 ( ortholog_many2many ) Mouse_ H2-Q2 ( ortholog_many2many ) Mouse_ H2-Q4 ( ortholog_many2many ) Mouse_ Gm8909 ( ortholog_many2many ) Mouse_ H2-Q7 ( ortholog_many2many ) Mouse_ H2-M11 ( ortholog_many2many ) Mouse_ H2-Q10 ( ortholog_many2many ) Mouse_ H2-M10.1 ( ortholog_many2many ) Mouse_ Gm11127 ( ortholog_many2many ) Mouse_ H2-M9 ( ortholog_many2many ) Mouse_ H2-T23 ( ortholog_many2many ) Mouse_ H2-M5 ( ortholog_many2many ) Mouse_ H2-M3 ( ortholog_many2many ) Mouse_ H2-M10.3 ( ortholog_many2many ) Mouse_ H2-M10.2 ( ortholog_many2many ) Mouse_ H2-Q6 ( ortholog_many2many ) Mouse_ H2-T22 ( ortholog_many2many ) Mouse_ H2-M10.5 ( ortholog_many2many ) Mouse_ Gm7030 ( ortholog_many2many ) Mouse_ H2-T10 ( ortholog_many2many ) Mouse_ H2-M2 ( ortholog_many2many ) Mouse_ 2410137M14Rik ( ortholog_many2many ) Mouse_ H2-K1 ( ortholog_many2many ) Rat_ AABR07072807.1 ( ortholog_many2many ) Rat_ RT1-S2 ( ortholog_many2many ) Rat_ RT1-M1-4 ( ortholog_many2many ) Rat_ RT1-CE16 ( ortholog_many2many ) Rat_ RT1-S3 ( ortholog_many2many ) Rat_ AABR07044308.2 ( ortholog_many2many ) Rat_ RT1-M1-2 ( ortholog_many2many ) Rat_ AABR07044383.1 ( ortholog_many2many ) Rat_ AABR07044308.1 ( ortholog_many2many ) Rat_ RT1-M3-1 ( ortholog_many2many ) Rat_ RT1-CE14 ( ortholog_many2many ) Rat_ RT1-CE11 ( ortholog_many2many ) Rat_ RT1-N3 ( ortholog_many2many ) Rat_ RT1-CE2 ( ortholog_many2many ) Rat_ RT1-CE1 ( ortholog_many2many ) Rat_ AABR07044397.1 ( ortholog_many2many ) Rat_ AABR07044362.1 ( ortholog_many2many ) Rat_ RT1-M2 ( ortholog_many2many ) Rat_ RT1-M6-2 ( ortholog_many2many ) Rat_ RT1-M5 ( ortholog_many2many ) Rat_ RT1-M10-1 ( ortholog_many2many ) Rat_ RT1-N2 ( ortholog_many2many )
Ohnologs	NA
Paralogs	MR1, AZGP1, MICA, HFE, MICB, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, CD1A, CD1D, CD1C, RAET1E, ULBP3, ULBP1, CD1E, HLA-B, HLA-C, HLA-G, HLA-F, HLA-E
Tissue	NA
Tissue Specificity	Ubiquitous. {ECO:0000305}.
Pharmacological Animal Models	NA
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1AKJ (X-ray 2.65A ) 1AO7 (X-ray 2.60A ) 1AQD (X-ray 2.45A ) 1B0G (X-ray 2.50A ) 1B0R (X-ray 2.90A ) 1BD2 (X-ray 2.50A ) 1DUY (X-ray 2.15A ) 1DUZ (X-ray 1.80A ) 1EEY (X-ray 2.25A ) 1EEZ (X-ray 2.30A ) 1HHG (X-ray 2.60A ) 1HHH (X-ray 3.00A ) 1HHI (X-ray 2.50A ) 1HHJ (X-ray 2.50A ) 1HHK (X-ray 2.50A ) 1HLA (X-ray 3.50A ) 1HSB (X-ray 1.90A ) 1I1F (X-ray 2.80A ) 1I1Y (X-ray 2.20A ) 1I4F (X-ray 1.40A ) 1I7R (X-ray 2.20A ) 1I7T (X-ray 2.80A ) 1I7U (X-ray 1.80A ) 1IM3 (X-ray 2.20A ) 1JF1 (X-ray 1.85A ) 1JHT (X-ray 2.15A ) 1LP9 (X-ray 2.00A ) 1OGA (X-ray 1.40A ) 1P7Q (X-ray 3.40A ) 1Q94 (X-ray 2.40A ) 1QEW (X-ray 2.20A ) 1QR1 (X-ray 2.40A ) 1QRN (X-ray 2.80A ) 1QSE (X-ray 2.80A ) 1QSF (X-ray 2.80A ) 1QVO (X-ray 2.22A ) 1S8D (X-ray 2.20A ) 1S9W (X-ray 2.20A ) 1S9X (X-ray 2.50A ) 1S9Y (X-ray 2.30A ) 1T1W (X-ray 2.20A ) 1T1X (X-ray 2.20A ) 1T1Y (X-ray 2.00A ) 1T1Z (X-ray 1.90A ) 1T20 (X-ray 2.20A ) 1T21 (X-ray 2.19A ) 1T22 (X-ray 2.20A ) 1TMC (X-ray 2.30A ) 1TVB (X-ray 1.80A ) 1TVH (X-ray 1.80A ) 1W72 (X-ray 2.15A ) 1X7Q (X-ray 1.45A ) 2AV1 (X-ray 1.95A ) 2AV7 (X-ray 2.05A ) 2BCK (X-ray 2.80A ) 2BNQ (X-ray 1.70A ) 2BNR (X-ray 1.90A ) 2C7U (X-ray 2.38A ) 2CLR (X-ray 2.00A ) 2F53 (X-ray 2.10A ) 2F54 (X-ray 2.70A ) 2GIT (X-ray 1.70A ) 2GJ6 (X-ray 2.56A ) 2GT9 (X-ray 1.75A ) 2GTW (X-ray 1.55A ) 2GTZ (X-ray 1.70A ) 2GUO (X-ray 1.90A ) 2HLA (X-ray 2.60A ) 2HN7 (X-ray 1.60A ) 2J8U (X-ray 2.88A ) 2JCC (X-ray 2.50A ) 2P5E (X-ray 1.89A ) 2P5W (X-ray 2.20A ) 2PYE (X-ray 2.30A ) 2UWE (X-ray 2.40A ) 2V2W (X-ray 1.60A ) 2V2X (X-ray 1.60A ) 2VLJ (X-ray 2.40A ) 2VLK (X-ray 2.50A ) 2VLL (X-ray 1.60A ) 2VLR (X-ray 2.30A ) 2X4N (X-ray 2.34A ) 2X4O (X-ray 2.30A ) 2X4P (X-ray 2.30A ) 2X4Q (X-ray 1.90A ) 2X4R (X-ray 2.30A ) 2X4S (X-ray 2.55A ) 2X4T (X-ray 2.30A ) 2X4U (X-ray 2.10A ) 2X70 (X-ray 2.00A ) 2XPG (X-ray 2.60A ) 3BGM (X-ray 1.60A ) 3BH8 (X-ray 1.65A ) 3BH9 (X-ray 1.70A ) 3BHB (X-ray 2.20A ) 3BO8 (X-ray 1.80A ) 3D25 (X-ray 1.30A ) 3D39 (X-ray 2.81A ) 3D3V (X-ray 2.80A ) 3FQN (X-ray 1.65A ) 3FQR (X-ray 1.70A ) 3FQT (X-ray 1.80A ) 3FQU (X-ray 1.80A ) 3FQW (X-ray 1.93A ) 3FQX (X-ray 1.70A ) 3FT2 (X-ray 1.80A ) 3FT3 (X-ray 1.95A ) 3FT4 (X-ray 1.90A ) 3GIV (X-ray 2.00A ) 3GJF (X-ray 1.90A ) 3GSN (X-ray 2.80A ) 3GSO (X-ray 1.60A ) 3GSQ (X-ray 2.12A ) 3GSR (X-ray 1.95A ) 3GSU (X-ray 1.80A ) 3GSV (X-ray 1.90A ) 3GSW (X-ray 1.81A ) 3GSX (X-ray 2.10A ) 3H7B (X-ray 1.88A ) 3H9H (X-ray 2.00A ) 3H9S (X-ray 2.70A ) 3HAE (X-ray 2.90A ) 3HLA (X-ray 2.60A ) 3HPJ (X-ray 2.00A ) 3I6G (X-ray 2.20A ) 3I6K (X-ray 2.80A ) 3I6L (X-ray 2.40A ) 3IXA (X-ray 2.10A ) 3KLA (X-ray 1.65A ) 3MGO (X-ray 2.30A ) 3MGT (X-ray 2.20A ) 3MR9 (X-ray 1.93A ) 3MRB (X-ray 1.40A ) 3MRC (X-ray 1.80A ) 3MRD (X-ray 1.70A ) 3MRE (X-ray 1.10A ) 3MRF (X-ray 2.30A ) 3MRG (X-ray 1.30A ) 3MRH (X-ray 2.40A ) 3MRI (X-ray 2.10A ) 3MRJ (X-ray 1.87A ) 3MRK (X-ray 1.40A ) 3MRL (X-ray 2.41A ) 3MRM (X-ray 1.90A ) 3MRN (X-ray 2.30A ) 3MRO (X-ray 2.35A ) 3MRP (X-ray 2.10A ) 3MRQ (X-ray 2.20A ) 3MRR (X-ray 1.60A ) 3MYJ (X-ray 1.89A ) 3NFN (X-ray 2.39A ) 3O3A (X-ray 1.80A ) 3O3B (X-ray 1.90A ) 3O3D (X-ray 1.70A ) 3O3E (X-ray 1.85A ) 3O4L (X-ray 2.54A ) 3PWJ (X-ray 1.70A ) 3PWL (X-ray 1.65A ) 3PWN (X-ray 1.60A ) 3PWP (X-ray 2.69A ) 3QDG (X-ray 2.69A ) 3QDJ (X-ray 2.30A ) 3QDM (X-ray 2.80A ) 3QEQ (X-ray 2.59A ) 3QFD (X-ray 1.68A ) 3QFJ (X-ray 2.29A ) 3QZW (X-ray 2.80A ) 3REW (X-ray 1.90A ) 3RL1 (X-ray 2.00A ) 3RL2 (X-ray 2.39A ) 3TO2 (X-ray 2.60A ) 3UTQ (X-ray 1.67A ) 3UTS (X-ray 2.71A ) 3UTT (X-ray 2.60A ) 3V5D (X-ray 2.00A ) 3V5H (X-ray 1.63A ) 3V5K (X-ray 2.31A ) 3VXM (X-ray 2.50A ) 3VXN (X-ray 1.95A ) 3VXO (X-ray 2.61A ) 3VXP (X-ray 2.50A ) 3VXR (X-ray 2.40A ) 3VXS (X-ray 1.80A ) 3VXU (X-ray 2.70A ) 3W0W (X-ray 2.60A ) 3WL9 (X-ray 1.66A ) 3WLB (X-ray 2.00A ) 4E5X (X-ray 1.95A ) 4EMZ (X-ray 2.90A ) 4EN2 (X-ray 2.58A ) 4EUP (X-ray 2.88A ) 4F7M (X-ray 2.40A ) 4F7P (X-ray 1.90A ) 4F7T (X-ray 1.70A ) 4FTV (X-ray 2.74A ) 4GKN (X-ray 2.75A ) 4GKS (X-ray 2.35A ) 4HWZ (X-ray 2.40A ) 4HX1 (X-ray 1.80A ) 4I48 (X-ray 2.80A ) 4I4W (X-ray 1.77A ) 4JFD (X-ray 2.46A ) 4JFE (X-ray 2.70A ) 4JFF (X-ray 2.43A ) 4JFO (X-ray 2.11A ) 4JFP (X-ray 1.91A ) 4JFQ (X-ray 1.90A ) 4K7F (X-ray 2.00A ) 4L29 (X-ray 3.09A ) 4L3C (X-ray 2.64A ) 4L3E (X-ray 2.56A ) 4MJ5 (X-ray 2.40A ) 4MJ6 (X-ray 2.57A ) 4MNQ (X-ray 2.74A ) 4N8V (X-ray 2.50A ) 4NNX (X-ray 2.10A ) 4NNY (X-ray 1.90A ) 4NO0 (X-ray 2.70A ) 4NO2 (X-ray 2.00A ) 4NO3 (X-ray 1.70A ) 4NO5 (X-ray 2.10A ) 4NQV (X-ray 2.39A ) 4NQX (X-ray 2.00A ) 4OV5 (X-ray 2.20A ) 4QOK (X-ray 3.00A ) 4U6X (X-ray 1.68A ) 4U6Y (X-ray 1.47A ) 4UQ2 (X-ray 2.43A ) 4UQ3 (X-ray 2.10A ) 4WJ5 (X-ray 1.65A ) 4WU5 (X-ray 2.40A ) 4WU7 (X-ray 2.30A ) 4WUU (X-ray 3.05A ) 5BRZ (X-ray 2.62A ) 5BS0 (X-ray 2.40A ) 5C07 (X-ray 2.11A ) 5C08 (X-ray 2.33A ) 5C09 (X-ray 2.48A ) 5C0A (X-ray 2.46A ) 5C0B (X-ray 2.03A ) 5C0C (X-ray 1.97A ) 5C0D (X-ray 1.68A ) 5C0E (X-ray 1.49A ) 5C0F (X-ray 1.46A ) 5C0G (X-ray 1.37A ) 5C0I (X-ray 1.53A ) 5C0J (X-ray 1.64A ) 5D2L (X-ray 3.51A ) 5D2N (X-ray 2.10A ) 5D9S (X-ray 1.87A ) 5DDH (X-ray 1.50A ) 5E00 (X-ray 1.70A ) 5E6I (X-ray 4.00A ) 5E9D (X-ray 2.51A ) 5ENW (X-ray 1.85A ) 5EOT (X-ray 2.10A ) 5EU3 (X-ray 1.97A ) 5EU4 (X-ray 2.12A ) 5EU5 (X-ray 1.54A ) 5EU6 (X-ray 2.02A ) 5EUO (X-ray 2.10A ) 5F7D (X-ray 2.30A ) 5F9J (X-ray 2.51A ) 5FA3 (X-ray 1.86A ) 5FA4 (X-ray 2.40A ) 5FDW (X-ray 2.70A ) 5GRD (X-ray 1.80A ) 5GRG (X-ray 1.94A ) 5GSD (X-ray 2.30A ) 5HGA (X-ray 2.20A ) 5HGB (X-ray 2.40A ) 5HGD (X-ray 2.07A ) 5HGH (X-ray 2.39A ) 5HHM (X-ray 2.50A ) 5HHN (X-ray 2.03A ) 5HHO (X-ray 2.95A ) 5HHP (X-ray 1.90A ) 5HHQ (X-ray 2.10A ) 5HYJ (X-ray 3.06A ) 5IRO (X-ray 2.64A ) 5ISZ (X-ray 2.06A ) 5JHD (X-ray 2.46A ) 5JZI (X-ray 2.50A ) 5MEN (X-ray 2.81A ) 5MEO (X-ray 1.77A ) 5MEP (X-ray 2.71A ) 5MEQ (X-ray 2.27A ) 5MER (X-ray 1.88A ) 5N1Y (X-ray 1.39A ) 5N6B (X-ray 1.71A ) 5NHT (X-ray 3.20A ) 5NME (X-ray 2.94A ) 5NMF (X-ray 2.89A ) 5NMG (X-ray 2.75A ) 5NMH (X-ray 1.55A ) 5NMK (X-ray 1.66A ) 5NQK (X-ray 3.25A ) 5SWQ (X-ray 2.00A ) 5TEZ (X-ray 1.70A ) 5W1W (X-ray 3.10A ) 5WJL (X-ray 3.15A ) 5WJN (X-ray 2.85A ) 5WKF (X-ray 2.95A ) 5WKH (X-ray 3.20A ) 5WSH (X-ray 2.00A ) 5WWI (X-ray 3.19A ) 5WWJ (X-ray 2.29A ) 5WWU (X-ray 2.79A ) 5WXC (X-ray 2.29A ) 5WXD (X-ray 3.29A ) 5XOV (X-ray 2.68A ) 5YXN (X-ray 2.03A ) 5YXU (X-ray 2.70A ) 6AM5 (X-ray 2.39A ) 6AMT (X-ray 2.50A ) 6AMU (X-ray 2.15A ) 6APN (X-ray 2.22A ) 6AT9 (X-ray 2.95A ) 6D78 (X-ray 2.35A ) 6D7G (X-ray 2.75A ) 6DKP (X-ray 2.97A ) 6EI2 (X-ray 1.61A ) 6ENY (EM 5.80A ) 6EQA (X-ray 3.16A ) 6EQB (X-ray 2.81A ) 6EWA (X-ray 2.39A ) 6EWC (X-ray 3.20A ) 6EWO (X-ray 2.30A ) 6G3J (X-ray 2.45A ) 6G3K (X-ray 2.90A ) 6ID4 (X-ray 2.40A ) 6J1W (X-ray 1.50A ) 6J29 (X-ray 1.60A ) 6J2A (X-ray 1.40A ) 6JOZ (X-ray 1.35A ) 6JP3 (X-ray 1.66A ) 6MPP (NMR - ) 6NCA (X-ray 3.30A ) 6O9B (X-ray 2.20A ) 6O9C (X-ray 2.45A ) 6OPD (X-ray 1.79A ) 6PBH (X-ray 1.89A ) 6PTB (X-ray 2.15A ) 6PTE (X-ray 1.90A ) 6Q3K (X-ray 1.50A ) 6Q3S (X-ray 2.50A ) 6R2L (X-ray 2.30A ) 6RP9 (X-ray 3.12A ) 6RPA (X-ray 2.56A ) 6RPB (X-ray 2.50A ) 6RSY (X-ray 2.95A ) 6SS7 (X-ray 2.50A ) 6SS8 (X-ray 2.24A ) 6SS9 (X-ray 2.70A ) 6SSA (X-ray 2.11A ) 7L1B (X-ray 2.04A ) 7L1C (X-ray 1.96A ) 7L1D (X-ray 3.11A ) 7MLE (X-ray 2.20A ) 7PHR (EM 3.08A ) 7QPD (EM 3.73A ) 7RM4 (X-ray 3.33A ) 7RRG (X-ray 2.12A )
DBSNP	rs2075684 rs2075684 rs1059423 rs41559117 rs1059449 rs199474430 rs199474436 rs78306866 rs199474457 rs1071742 rs1136688 rs1136692 rs1071743 rs1136695 rs1136697 rs1136700 rs1136702 rs1059488 rs1059509 rs1059516 rs1059520 rs1059526 rs9256983 rs9260156 rs1059542 rs879577815 rs3098019
Subcellular location [CC]	Cell membrane {ECO:0000269\|PubMed:21263072, ECO:0000269\|PubMed:25880248, ECO:0000269\|PubMed:8805302}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305\|PubMed:8805302}; Single-pass type I membrane protein {ECO:0000255}.
Mouse PG classification	NA
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