Gene Information
Gene NameHK2
OrganismHomo sapiens (Human)
Gene Length917
Protein NamesHexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)
Target Namehexokinase-2
Target TypeClinical trial target
Gene Age987 ( ENSG00000159399 )
Evolutionary StageEuk+Bac
AlphaFoldDBP52789
Gene CardHK2
Uniprot IDP52789
PfamPF00349; PF03727
In ASDyes
Allosteric Predictionyes (1.000146433)
Ortholog in AnimalsAlpaca_ HK2 ( ortholog_one2one )
Dog_ HK2 ( ortholog_one2one )
GuineaPig_ HK2 ( ortholog_one2one )
Macaque_ HK2 ( ortholog_one2one )
Mouse_ Hk2 ( ortholog_one2one )
Pig_ HK2 ( ortholog_one2one )
Rat_ Hk2 ( ortholog_one2one )
Rabbit_ HK2 ( ortholog_one2one )
OhnologsHKDC1, HK1, HK3
ParalogsHK1, HKDC1, HK3, GCK
TissueNA
Tissue SpecificityPredominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. {ECO:0000269|PubMed:8250948}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2NZT  (X-ray  2.45A  )  5HEX  (X-ray  2.73A  )  5HFU  (X-ray  2.92A  )  5HG1  (X-ray  2.76A  ) 
DBSNP rs2229621  rs28363006  rs28363015  rs28363016  rs61748096  rs28363029  rs145124653  rs185927605  rs28363057  rs2229629  rs28363065 
Subcellular location [CC]Mitochondrion outer membrane {ECO:0000269|PubMed:18350175};
Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:18350175}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:29298880}.
Mouse PG classificationNA
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