| Gene Information | |
|---|---|
| Gene Name | HJV |
| Organism | Homo sapiens (Human) |
| Gene Length | 426 |
| Protein Names | Hemojuvelin (Hemochromatosis type 2 protein) (Hemojuvelin BMP coreceptor) (RGM domain family member C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000168509 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6ZVN8 |
| Gene Card | HJV |
| Uniprot ID | Q6ZVN8 |
| Pfam | PF06534; PF06535 |
| In ASD | no |
| Allosteric Prediction | no (-0.226340677) |
| Ortholog in Animals | Alpaca_ HJV ( ortholog_one2many ) GuineaPig_ HJV ( ortholog_one2one ) Macaque_ HJV ( ortholog_one2one ) Mouse_ Hjv ( ortholog_one2one ) Pig_ HJV ( ortholog_one2one ) Rat_ Hjv ( ortholog_one2one ) Rabbit_ HJV ( ortholog_one2one ) |
| Ohnologs | RGMB, RGMA |
| Paralogs | RGMA, RGMB |
| Tissue | heart, liver, skeletal.muscle, artery |
| Tissue Specificity | Adult and fetal liver, heart, and skeletal muscle. {ECO:0000269|PubMed:14647275}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4UI1 (X-ray 2.35A ) 6Z3L (X-ray 2.51A ) |
| DBSNP | rs28940586 rs1553769752 rs1553769745 rs74315327 rs782125244 rs1553769659 rs782708481 rs1553769634 rs1553769627 rs74315325 rs863224819 rs782493762 rs7540883 rs74315323 rs121434374 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Also released in the extracellular space. {ECO:0000269|PubMed:25156943}. |
| Mouse PG classification | NA |
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