Gene Information
Gene NameSCN4A
OrganismHomo sapiens (Human)
Gene Length1836
Protein NamesSodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4)
Target Namevoltage-gated sodium channel alpha subunit
Target TypeNA
Gene Age645 ( ENSG00000007314 )
Evolutionary StageEukaryota
AlphaFoldDBP35499
Gene CardSCN4A
Uniprot IDP35499
PfamPF00520; PF06512
In ASDno
Allosteric Predictionyes (1.112852391)
Ortholog in AnimalsAlpaca_ SCN4A ( ortholog_one2one )
Dog_ SCN4A ( ortholog_one2one )
GuineaPig_ SCN4A ( ortholog_one2one )
Macaque_ SCN4A ( ortholog_one2one )
Mouse_ Scn4a ( ortholog_one2one )
Pig_ SCN4A ( ortholog_one2one )
Rat_ Scn4a ( ortholog_one2one )
Rabbit_ SCN4A ( ortholog_one2one )
OhnologsSCN2A, SCN7A, SCN1A, SCN3A, SCN9A, SCN10A, SCN8A
ParalogsSCN11A, CACNA1C, CATSPER1, CACNA1E, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, TPCN2
Tissueadipose.tissue, skeletal.muscle
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.057143(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6AGF  (EM  3.20A  )  6MBA  (X-ray  1.80A  )  6MC9  (X-ray  3.30A  ) 
DBSNP rs1303471186  rs1248025530  rs121908561  rs933258893  rs527236148  rs764718003  rs80338951  rs1597985462  rs121908552  rs372631097  rs6504191  rs1047705  rs80338784  rs80338785  rs80338785  rs80338788  rs80338785  rs121908556  rs121908557  rs121908556  rs80338956  rs80338957  rs749400108  rs62070884  rs121908546  rs373150395  rs527236149  rs80338789  rs1287863349  rs527236150  rs80338958  rs121908555  rs121908549  rs121908551  rs121908560  rs80338792  rs80338792  rs80338792  rs1567817380  rs121908547  rs2058194  rs121908550  rs1598405334  rs121908553  rs121908544  rs121908545  rs121908545  rs879253789  rs121908554  rs863225046  rs121908559  rs763893717  rs121908548  rs80338962  rs1064794243 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:12766226, ECO:0000269|PubMed:15318338, ECO:0000269|PubMed:16890191, ECO:0000269|PubMed:17898326, ECO:0000269|PubMed:18690054, ECO:0000269|PubMed:19347921, ECO:0000269|PubMed:25707578, ECO:0000269|PubMed:26659129, ECO:0000269|PubMed:26700687, ECO:0000269|PubMed:29992740, ECO:0000269|PubMed:30190309};
Multi-pass membrane protein {ECO:0000269|PubMed:30190309}.
Mouse PG classificationHPG
click here to return to the previous page