| Gene Information | |
|---|---|
| Gene Name | HIRA |
| Organism | Homo sapiens (Human) |
| Gene Length | 1017 |
| Protein Names | Protein HIRA (TUP1-like enhancer of split protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000100084 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P54198 |
| Gene Card | HIRA |
| Uniprot ID | P54198 |
| Pfam | PF07569; PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.560164111) |
| Ortholog in Animals | Alpaca_ HIRA ( ortholog_one2one ) Dog_ HIRA ( ortholog_one2one ) GuineaPig_ HIRA ( ortholog_one2one ) Macaque_ HIRA ( ortholog_one2one ) Mouse_ Hira ( ortholog_one2one ) Pig_ HIRA ( ortholog_one2one ) Rat_ Hira ( ortholog_one2one ) Rabbit_ HIRA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. {ECO:0000269|PubMed:9063745}. |
| Pharmacological Animal Models | 0.016289(Chimpanzee);0.024788(Mouse);0.001899(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2I32 (X-ray 2.70A ) 5YJE (X-ray 2.45A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence. |
| Mouse PG classification | NA |
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