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Gene Information
Gene Name
MPS1
Organism
Homo sapiens (Human)
Gene Length
857
Protein Names
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
P33981
Gene Card
TTK
Uniprot ID
P33981
Pfam
PF00069
In ASD
yes
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
Present in rapidly proliferating cell lines.
Pharmacological Animal Models
0.050380(Chimpanzee);0.058983(Mouse);NULL(Rat);0.016667(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
2X9E
(X-ray
3.10A
)
2ZMC
(X-ray
3.14A
)
2ZMD
(X-ray
2.88A
)
3CEK
(X-ray
2.30A
)
3DBQ
(X-ray
2.70A
)
3GFW
(X-ray
2.74A
)
3H9F
(X-ray
2.60A
)
3HMN
(X-ray
2.70A
)
3HMO
(X-ray
2.40A
)
3HMP
(X-ray
2.30A
)
3VQU
(X-ray
2.40A
)
3W1F
(X-ray
2.70A
)
3WYX
(X-ray
2.90A
)
3WYY
(X-ray
3.05A
)
3WZJ
(X-ray
2.75A
)
3WZK
(X-ray
2.30A
)
4B94
(X-ray
2.20A
)
4BHZ
(X-ray
2.85A
)
4BI0
(X-ray
2.84A
)
4BI1
(X-ray
2.70A
)
4BI2
(X-ray
3.11A
)
4C4E
(X-ray
2.60A
)
4C4F
(X-ray
2.36A
)
4C4G
(X-ray
2.65A
)
4C4H
(X-ray
2.80A
)
4C4I
(X-ray
2.65A
)
4C4J
(X-ray
2.50A
)
4CV8
(X-ray
3.00A
)
4CV9
(X-ray
2.50A
)
4CVA
(X-ray
2.50A
)
4D2S
(X-ray
2.50A
)
4H7X
(X-ray
2.60A
)
4H7Y
(X-ray
1.80A
)
4JS8
(X-ray
1.94A
)
4JT3
(X-ray
2.20A
)
4O6L
(X-ray
2.38A
)
4ZEG
(X-ray
2.33A
)
5AP0
(X-ray
2.15A
)
5AP1
(X-ray
2.05A
)
5AP2
(X-ray
2.80A
)
5AP3
(X-ray
2.70A
)
5AP4
(X-ray
2.85A
)
5AP5
(X-ray
2.80A
)
5AP6
(X-ray
2.10A
)
5AP7
(X-ray
2.45A
)
5EH0
(X-ray
2.18A
)
5EHL
(X-ray
2.66A
)
5EHO
(X-ray
2.18A
)
5EHY
(X-ray
2.26A
)
5EI2
(X-ray
2.67A
)
5EI6
(X-ray
2.01A
)
5EI8
(X-ray
2.17A
)
5LJJ
(X-ray
3.00A
)
5MRB
(X-ray
2.20A
)
5N7V
(X-ray
2.52A
)
5N84
(X-ray
2.30A
)
5N87
(X-ray
2.29A
)
5N93
(X-ray
2.10A
)
5N9S
(X-ray
2.30A
)
5NA0
(X-ray
2.90A
)
5NAD
(X-ray
2.80A
)
5NTT
(X-ray
2.75A
)
5O91
(X-ray
3.20A
)
6B4W
(X-ray
2.90A
)
6GVJ
(X-ray
2.41A
)
6H3K
(X-ray
2.48A
)
6N6O
(X-ray
2.60A
)
6TN9
(X-ray
2.60A
)
6TNB
(X-ray
2.65A
)
6TNC
(X-ray
2.30A
)
6TND
(X-ray
2.58A
)
7CHM
(X-ray
2.65A
)
7CHN
(X-ray
2.40A
)
7CHT
(X-ray
2.40A
)
7CIL
(X-ray
2.30A
)
7CJA
(X-ray
2.49A
)
7CLH
(X-ray
2.90A
)
7LQD
(X-ray
1.95A
)
DBSNP
rs2230513
rs2230512
Subcellular location [CC]
NA
Mouse PG classification
NA
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