Gene Information | |
---|---|
Gene Name | HIPK1 |
Organism | Homo sapiens (Human) |
Gene Length | 1210 |
Protein Names | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) |
Target Name | NA |
Target Type | NA |
Gene Age | 680 ( ENSG00000163349 ) |
Evolutionary Stage | Eukaryota |
AlphaFoldDB | Q86Z02 |
Gene Card | HIPK1 |
Uniprot ID | Q86Z02 |
Pfam | PF00069 |
In ASD | no |
Allosteric Prediction | no (-0.257808793) |
Ortholog in Animals | Alpaca_ HIPK1 ( ortholog_one2one ) Dog_ HIPK1 ( ortholog_one2one ) GuineaPig_ HIPK1 ( ortholog_one2one ) Macaque_ HIPK1 ( ortholog_one2one ) Mouse_ Hipk1 ( ortholog_one2one ) Pig_ HIPK1 ( ortholog_one2one ) Rat_ Hipk1 ( ortholog_one2one ) Rabbit_ HIPK1 ( ortholog_one2one ) |
Ohnologs | HIPK2, HIPK3 |
Paralogs | CLK1, HIPK3, DYRK4, DYRK1B, CLK3, HIPK4, DYRK3, HIPK2, CLK4, DYRK2, DYRK1A, CLK2 |
Tissue | NA |
Tissue Specificity | Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. Expressed in both androgen-dependent and androgen-independent prostate cancer cells (PubMed:28289210). {ECO:0000269|PubMed:12529400, ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:28289210}. |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
|
Gene Ontology (molecular function) |
|
PDB | NA |
DBSNP | rs35324789 rs34335651 |
Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:18219322, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:28289210}. Cytoplasm {ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:18219322, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:28289210}. Nucleus speckle {ECO:0000269|PubMed:16390825}. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation. {ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:18219322}. |
Mouse PG classification | NA |
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