Gene Information
Gene NameHIPK1
OrganismHomo sapiens (Human)
Gene Length1210
Protein NamesHomeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000163349 )
Evolutionary StageEukaryota
AlphaFoldDBQ86Z02
Gene CardHIPK1
Uniprot IDQ86Z02
PfamPF00069
In ASDno
Allosteric Predictionno (-0.257808793)
Ortholog in AnimalsAlpaca_ HIPK1 ( ortholog_one2one )
Dog_ HIPK1 ( ortholog_one2one )
GuineaPig_ HIPK1 ( ortholog_one2one )
Macaque_ HIPK1 ( ortholog_one2one )
Mouse_ Hipk1 ( ortholog_one2one )
Pig_ HIPK1 ( ortholog_one2one )
Rat_ Hipk1 ( ortholog_one2one )
Rabbit_ HIPK1 ( ortholog_one2one )
OhnologsHIPK2, HIPK3
ParalogsCLK1, HIPK3, DYRK4, DYRK1B, CLK3, HIPK4, DYRK3, HIPK2, CLK4, DYRK2, DYRK1A, CLK2
TissueNA
Tissue SpecificityUbiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. Expressed in both androgen-dependent and androgen-independent prostate cancer cells (PubMed:28289210). {ECO:0000269|PubMed:12529400, ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:28289210}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs35324789  rs34335651 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:18219322, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:28289210}. Cytoplasm {ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:18219322, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:28289210}. Nucleus speckle {ECO:0000269|PubMed:16390825}. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation. {ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:18219322}.
Mouse PG classificationNA
click here to return to the previous page