| Gene Information | |
|---|---|
| Gene Name | VSIR |
| Organism | Homo sapiens (Human) |
| Gene Length | 311 |
| Protein Names | V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) |
| Target Name | v-set immunoregulatory receptor |
| Target Type | Clinical trial target |
| Gene Age | 132 ( ENSG00000107738 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9H7M9 |
| Gene Card | VSIR |
| Uniprot ID | Q9H7M9 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-1.141351108) |
| Ortholog in Animals | Alpaca_ VSIR ( ortholog_one2one ) Dog_ VSIR ( ortholog_one2one ) Macaque_ VSIR ( ortholog_one2one ) Mouse_ Vsir ( ortholog_one2one ) Rabbit_ VSIR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MXRA8, VSIG1, IGSF11, JAM3, VSIG2, JAM2, ESAM, F11R, MUC15, GPA33, CXADR, VSTM2B, VSIG8, CLMP |
| Tissue | NA |
| Tissue Specificity | Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues. {ECO:0000269|PubMed:24691993}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6MVL (X-ray 1.61A ) 6OIL (X-ray 1.85A ) 6U6V (X-ray 1.90A ) |
| DBSNP | rs3747869 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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