| Gene Information | |
|---|---|
| Gene Name | HINT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 126 |
| Protein Names | Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) |
| Target Name | histidine triad nucleotide-binding protein 1 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000169567 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P49773 |
| Gene Card | HINT1 |
| Uniprot ID | P49773 |
| Pfam | PF01230 |
| In ASD | no |
| Allosteric Prediction | yes (0.05689207) |
| Ortholog in Animals | Alpaca_ HINT1 ( ortholog_one2one ) Dog_ HINT1 ( ortholog_one2many ) GuineaPig_ HINT1 ( ortholog_one2one ) Macaque_ HINT1 ( ortholog_one2one ) Mouse_ Hint1 ( ortholog_one2one ) Pig_ HINT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FHIT, HINT2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1AV5 (X-ray 2.00A ) 1KPA (X-ray 2.00A ) 1KPB (X-ray 2.00A ) 1KPC (X-ray 2.20A ) 1KPE (X-ray 1.80A ) 1KPF (X-ray 1.50A ) 3TW2 (X-ray 1.38A ) 4EQE (X-ray 1.52A ) 4EQG (X-ray 1.52A ) 4EQH (X-ray 1.67A ) 4ZKL (X-ray 2.34A ) 4ZKV (X-ray 1.92A ) 5ED3 (X-ray 1.31A ) 5ED6 (X-ray 1.52A ) 5EMT (X-ray 1.50A ) 5I2E (X-ray 1.60A ) 5I2F (X-ray 1.25A ) 5IPB (X-ray 1.55A ) 5IPC (X-ray 1.30A ) 5IPD (X-ray 1.75A ) 5IPE (X-ray 1.45A ) 5KLY (X-ray 1.30A ) 5KLZ (X-ray 1.50A ) 5KM0 (X-ray 1.53A ) 5KM1 (X-ray 1.65A ) 5KM2 (X-ray 1.25A ) 5KM3 (X-ray 1.20A ) 5KM4 (X-ray 1.40A ) 5KM6 (X-ray 1.60A ) 5KMA (X-ray 1.55A ) 5KMB (X-ray 1.60A ) 5KMC (X-ray 1.35A ) 5O8I (X-ray 1.27A ) 5WA8 (X-ray 1.30A ) 5WA9 (X-ray 1.15A ) 5WAA (X-ray 1.10A ) 6B42 (X-ray 1.13A ) 6G9Z (X-ray 1.43A ) 6J53 (X-ray 1.52A ) 6J58 (X-ray 1.52A ) 6J5S (X-ray 1.02A ) 6J5Z (X-ray 1.30A ) 6J64 (X-ray 0.95A ) 6J65 (X-ray 1.42A ) 6N3V (X-ray 1.45A ) 6N3W (X-ray 1.75A ) 6N3X (X-ray 1.10A ) 6N3Y (X-ray 1.80A ) 6YQM (X-ray 1.02A ) 7Q2U (X-ray 2.27A ) |
| DBSNP | rs149782619 rs397514491 rs397514489 rs397514490 rs397514493 rs373849532 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10958787, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:8812426}. Nucleus {ECO:0000269|PubMed:10958787, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:9770345}. Note=Interaction with CDK7 leads to a more nuclear localization. {ECO:0000269|PubMed:10958787}. |
| Mouse PG classification | LPG |
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