| Gene Information | |
|---|---|
| Gene Name | HIF1AN |
| Organism | Homo sapiens (Human) |
| Gene Length | 349 |
| Protein Names | Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase) |
| Target Name | hypoxia-inducible factor 1-alpha inhibitor |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000166135 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9NWT6 |
| Gene Card | HIF1AN |
| Uniprot ID | Q9NWT6 |
| Pfam | PF13621 |
| In ASD | no |
| Allosteric Prediction | yes (0.400252056) |
| Ortholog in Animals | Alpaca_ HIF1AN ( ortholog_one2one ) Dog_ HIF1AN ( ortholog_one2one ) GuineaPig_ HIF1AN ( ortholog_one2one ) Macaque_ HIF1AN ( ortholog_one2one ) Mouse_ Hif1an ( ortholog_one2one ) Pig_ HIF1AN ( ortholog_one2one ) Rat_ Hif1an ( ortholog_one2one ) Rabbit_ HIF1AN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KDM8, JMJD7, TYW5, HSPBAP1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002202(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1H2K (X-ray 2.15A ) 1H2L (X-ray 2.25A ) 1H2M (X-ray 2.50A ) 1H2N (X-ray 2.84A ) 1IZ3 (X-ray 2.80A ) 1MZE (X-ray 2.20A ) 1MZF (X-ray 2.40A ) 1YCI (X-ray 2.70A ) 2CGN (X-ray 2.40A ) 2CGO (X-ray 2.30A ) 2ILM (X-ray 2.30A ) 2W0X (X-ray 2.12A ) 2WA3 (X-ray 2.50A ) 2WA4 (X-ray 2.50A ) 2XUM (X-ray 2.20A ) 2Y0I (X-ray 2.28A ) 2YC0 (X-ray 2.15A ) 2YDE (X-ray 2.28A ) 3D8C (X-ray 2.10A ) 3KCX (X-ray 2.60A ) 3KCY (X-ray 2.59A ) 3OD4 (X-ray 2.20A ) 3P3N (X-ray 2.40A ) 3P3P (X-ray 2.60A ) 4AI8 (X-ray 2.40A ) 4B7E (X-ray 2.50A ) 4B7K (X-ray 2.39A ) 4BIO (X-ray 2.45A ) 4JAA (X-ray 2.39A ) 4NR1 (X-ray 2.68A ) 4Z1V (X-ray 2.10A ) 4Z2W (X-ray 2.50A ) 5JWK (X-ray 2.30A ) 5JWL (X-ray 2.40A ) 5JWP (X-ray 2.10A ) 5OP6 (X-ray 2.45A ) 5OP8 (X-ray 2.30A ) 5OPC (X-ray 2.30A ) 6H9J (X-ray 1.83A ) 6HA6 (X-ray 1.98A ) 6HC8 (X-ray 1.90A ) 6HKP (X-ray 1.90A ) 6HL5 (X-ray 1.98A ) 6HL6 (X-ray 1.97A ) 6RUJ (X-ray 2.42A ) 7A1J (X-ray 1.90A ) 7A1K (X-ray 1.99A ) 7A1L (X-ray 2.29A ) 7A1M (X-ray 2.18A ) 7A1N (X-ray 2.01A ) 7A1O (X-ray 2.21A ) 7A1P (X-ray 1.76A ) 7A1Q (X-ray 1.75A ) 7A1S (X-ray 2.01A ) |
| DBSNP | rs2295778 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages. |
| Mouse PG classification | NA |
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