| Gene Information | |
|---|---|
| Gene Name | CHD1L |
| Organism | Homo sapiens (Human) |
| Gene Length | 897 |
| Protein Names | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000131778 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q86WJ1 |
| Gene Card | CHD1L |
| Uniprot ID | Q86WJ1 |
| Pfam | PF00271; PF00176 |
| In ASD | yes |
| Allosteric Prediction | yes (0.535816329) |
| Ortholog in Animals | Alpaca_ CHD1L ( ortholog_one2one ) Dog_ CHD1L ( ortholog_one2one ) GuineaPig_ CHD1L ( ortholog_one2one ) Macaque_ CHD1L ( ortholog_one2one ) Mouse_ Chd1l ( ortholog_one2one ) Pig_ CHD1L ( ortholog_one2one ) Rat_ Chd1l ( ortholog_one2one ) Rabbit_ CHD1L ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SMARCA1, RAD54B, HLTF, HELLS, SHPRH, BTAF1, ZRANB3, SMARCA5, TTF2, SMARCA2, CHD9, SMARCAL1, CHD3, RAD54L2, SMARCAD1, CHD4, ATRX, INO80, CHD6, SRCAP, CHD1, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | Frequently overexpressed in hepatomacellular carcinomas. {ECO:0000269|PubMed:18023026}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.045455(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6ZHX (EM 2.50A ) 6ZHY (EM 3.00A ) 7ENN (EM 2.80A ) 7EPU (X-ray 3.50A ) 7OTQ (EM 4.80A ) |
| DBSNP | rs11588753 rs17356233 rs13374920 rs2275249 rs1553974573 rs1180954265 rs139712616 rs4950394 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19661379}. Chromosome {ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:29220652, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34874266}. Note=Localizes at sites of DNA damage; recruited by histones H2B and H3 poly-ADP-ribosylated on 'Ser-6' and 'Ser-10', respectively (H2BS6ADPr and H3S10ADPr) by PARP1 or PARP2. {ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34874266}. |
| Mouse PG classification | NA |
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