| Gene Information | |
|---|---|
| Gene Name | HIBCH |
| Organism | Homo sapiens (Human) |
| Gene Length | 386 |
| Protein Names | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H) |
| Target Name | 3-hydroxyisobutyryl-coa hydrolase, mitochondrial |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000198130 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q6NVY1 |
| Gene Card | HIBCH |
| Uniprot ID | Q6NVY1 |
| Pfam | PF16113 |
| In ASD | no |
| Allosteric Prediction | no (-0.39094318) |
| Ortholog in Animals | Alpaca_ HIBCH ( ortholog_one2one ) Dog_ HIBCH ( ortholog_one2one ) GuineaPig_ HIBCH ( ortholog_one2one ) Macaque_ HIBCH ( ortholog_one2one ) Mouse_ Hibch ( ortholog_one2one ) Pig_ HIBCH ( ortholog_one2one ) Rat_ Hibch ( ortholog_one2one ) Rabbit_ HIBCH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ECI1, ECHS1, AUH, ECH1, CDY1, CDYL, CDY2A, CDY2B, CDY1B, CDYL2, ECHDC3, ECHDC2, ECHDC1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in liver and kidney, also detected in heart, muscle and brain (at protein level). Not detected in lung. {ECO:0000269|PubMed:8824301}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3BPT (X-ray 1.50A ) |
| DBSNP | rs1058180 rs121918329 |
| Subcellular location [CC] | Mitochondrion {ECO:0000250}. |
| Mouse PG classification | NA |
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