| Gene Information | |
|---|---|
| Gene Name | PLXNB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1909 |
| Protein Names | Plexin-B3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000198753 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9ULL4 |
| Gene Card | PLXNB3 |
| Uniprot ID | Q9ULL4 |
| Pfam | PF08337; PF20170; PF01437; PF01403; PF01833; PF18020; PF17960 |
| In ASD | no |
| Allosteric Prediction | no (-0.642156002) |
| Ortholog in Animals | Alpaca_ PLXNB3 ( ortholog_one2one ) Dog_ PLXNB3 ( ortholog_one2one ) GuineaPig_ PLXNB3 ( ortholog_one2one ) Mouse_ Plxnb3 ( ortholog_one2one ) Pig_ PLXNB3 ( ortholog_one2one ) Rat_ Plxnb3 ( ortholog_one2one ) Rabbit_ PLXNB3 ( ortholog_one2one ) |
| Ohnologs | PLXND1, PLXNA2, PLXNA1, PLXNB1, PLXNA4 |
| Paralogs | PLXNA3, PLXNA2, PLXNA1, PLXNA4, PLXNB1, PLXNB2, PLXNC1, PLXND1 |
| Tissue | NA |
| Tissue Specificity | Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines. {ECO:0000269|PubMed:16122393, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34360382 rs782213788 rs2266879 rs6643791 rs5987155 rs34762690 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}; Single-pass type I membrane protein {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}. Note=Colocalizes with RIT2/RIN at the plasma membrane. |
| Mouse PG classification | NA |
| click here to return to the previous page | |