Gene Information
Gene NamePLPP3
OrganismHomo sapiens (Human)
Gene Length311
Protein NamesPhospholipid phosphatase 3 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000162407 )
Evolutionary StageEumetazoa
AlphaFoldDBO14495
Gene CardPLPP3
Uniprot IDO14495
PfamPF01569
In ASDno
Allosteric Predictionno (-0.163684166)
Ortholog in AnimalsAlpaca_ PLPP3 ( ortholog_one2one )
Dog_ PLPP3 ( ortholog_one2one )
GuineaPig_ PLPP3 ( ortholog_one2one )
Macaque_ PLPP3 ( ortholog_one2one )
Mouse_ Plpp3 ( ortholog_one2one )
Pig_ PLPP3 ( ortholog_one2one )
Rat_ Plpp3 ( ortholog_one2one )
Rabbit_ PLPP3 ( ortholog_one2one )
OhnologsPLPP1, PLPP2, PLPPR1
ParalogsPLPPR5, PLPPR1, PLPPR4, PLPP4, PLPP2, PLPPR3, PLPPR2, PLPP1, PLPP5
TissueNA
Tissue SpecificityUbiquitously expressed (PubMed:9305923, PubMed:12660161). Highly expressed in heart and placenta (PubMed:9305923). {ECO:0000269|PubMed:12660161, ECO:0000269|PubMed:9305923}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:12660161, ECO:0000269|PubMed:20123964, ECO:0000269|PubMed:9705349};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Basolateral cell membrane {ECO:0000269|PubMed:14527693};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23591818};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:23591818};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Golgi apparatus membrane {ECO:0000269|PubMed:23591818};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:23591818};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Membrane raft {ECO:0000269|PubMed:17005594};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Note=Cycles between the endoplasmic reticulum and the Golgi. {ECO:0000269|PubMed:23591818}.
Mouse PG classificationNA
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