Gene Information
Gene NamePRDX5
OrganismHomo sapiens (Human)
Gene Length214
Protein NamesPeroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)
Target Namethioredoxin reductase
Target TypeSuccessful target
Gene Age168 ( ENSG00000126432 )
Evolutionary StageEuk+Bac
AlphaFoldDBP30044
Gene CardPRDX5
Uniprot IDP30044
PfamPF08534
In ASDno
Allosteric Predictionyes (0.646293874)
Ortholog in AnimalsAlpaca_ PRDX5 ( ortholog_one2one )
GuineaPig_ PRDX5 ( ortholog_one2one )
Macaque_ PRDX5 ( ortholog_one2one )
Mouse_ Prdx5 ( ortholog_one2one )
Pig_ PRDX5 ( ortholog_one2one )
Rat_ Prdx5 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:10521424}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1H4O  (X-ray  1.95A  )  1HD2  (X-ray  1.50A  )  1OC3  (X-ray  2.00A  )  1URM  (X-ray  1.70A  )  2VL2  (X-ray  1.92A  )  2VL3  (X-ray  1.83A  )  2VL9  (X-ray  2.70A  )  3MNG  (X-ray  1.45A  )  4K7I  (X-ray  2.25A  )  4K7N  (X-ray  2.30A  )  4K7O  (X-ray  1.98A  )  4MMM  (X-ray  1.47A  ) 
DBSNP rs7938623 
Subcellular location [CC][Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}.;
[Isoform Cytoplasmic+peroxisomal]: Cytoplasm {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10751410}. Peroxisome matrix {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410}. Note=Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5. {ECO:0000269|PubMed:10514471}.
Mouse PG classificationNA
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