| Gene Information | |
|---|---|
| Gene Name | PTPRK |
| Organism | Homo sapiens (Human) |
| Gene Length | 1439 |
| Protein Names | Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000152894 ) 3 ( ENSG00000273993 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q15262 |
| Gene Card | PTPRK |
| Uniprot ID | Q15262 |
| Pfam | PF00041; PF07679; PF00629; PF00102 |
| In ASD | no |
| Allosteric Prediction | yes (0.593186853) |
| Ortholog in Animals | Alpaca_ PTPRK ( ortholog_one2one ) Dog_ PTPRK ( ortholog_one2one ) GuineaPig_ PTPRK ( ortholog_one2one ) Macaque_ PTPRK ( ortholog_one2one ) Mouse_ Ptprk ( ortholog_one2one ) Pig_ PTPRK ( ortholog_one2one ) Rabbit_ PTPRK ( ortholog_one2one ) |
| Ohnologs | PTPRM, PTPRT, PTPRU |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2C7S (X-ray 1.95A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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