| Gene Information | |
|---|---|
| Gene Name | EEF1E1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 174 |
| Protein Names | Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000124802 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43324 |
| Gene Card | EEF1E1 |
| Uniprot ID | O43324 |
| Pfam | PF00043 |
| In ASD | no |
| Allosteric Prediction | no (-0.8384577) |
| Ortholog in Animals | Alpaca_ EEF1E1 ( ortholog_one2one ) Dog_ EEF1E1 ( ortholog_one2one ) GuineaPig_ EEF1E1 ( ortholog_one2one ) Mouse_ Eef1e1 ( ortholog_one2one ) Pig_ EEF1E1 ( ortholog_one2one ) Rat_ Eef1e1 ( ortholog_one2one ) Rabbit_ EEF1E1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Down-regulated in various cancer tissues. {ECO:0000269|PubMed:15680327}. |
| Pharmacological Animal Models | 0.073995(Chimpanzee);0.055074(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2UZ8 (X-ray 2.00A ) 4BL7 (X-ray 1.89A ) 4BVX (X-ray 1.60A ) 4BVY (X-ray 1.99A ) 5BMU (X-ray 2.60A ) 5Y6L (X-ray 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15680327}. Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}. Nucleus {ECO:0000269|PubMed:15680327}. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage. |
| Mouse PG classification | NA |
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