| Gene Information | |
|---|---|
| Gene Name | HHIP |
| Organism | Homo sapiens (Human) |
| Gene Length | 700 |
| Protein Names | Hedgehog-interacting protein (HHIP) (HIP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000164161 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q96QV1 |
| Gene Card | HHIP |
| Uniprot ID | Q96QV1 |
| Pfam | PF03024; PF07995 |
| In ASD | no |
| Allosteric Prediction | no (-0.463550495) |
| Ortholog in Animals | Alpaca_ HHIP ( ortholog_one2one ) Dog_ HHIP ( ortholog_one2one ) GuineaPig_ HHIP ( ortholog_one2one ) Macaque_ HHIP ( ortholog_one2one ) Mouse_ Hhip ( ortholog_one2one ) Pig_ HHIP ( ortholog_one2one ) Rat_ Hhip ( ortholog_one2one ) Rabbit_ HHIP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HHIPL1, HHIPL2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. {ECO:0000269|PubMed:11435703, ECO:0000269|Ref.1}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WFT (X-ray 2.80A ) 2WFX (X-ray 3.20A ) 2WG3 (X-ray 2.60A ) 2WG4 (X-ray 3.15A ) 3HO3 (X-ray 2.90A ) 3HO4 (X-ray 3.10A ) 3HO5 (X-ray 3.01A ) 7PGK (X-ray 2.75A ) 7PGL (X-ray 2.63A ) 7PGM (X-ray 2.70A ) 7PGN (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=The last 22 C-terminal amino acids may participate in cell membrane attachment.; [Isoform 2]: Cytoplasm {ECO:0000305}. |
| Mouse PG classification | NA |
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