Gene Information
Gene NameHHAT
OrganismHomo sapiens (Human)
Gene Length493
Protein NamesProtein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Melanoma antigen recognized by T-cells 2) (MART-2) (Skinny hedgehog protein 1)
Target NameNA
Target TypeNA
Gene Age886 ( ENSG00000054392 )
3 ( ENSG00000280680 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ5VTY9
Gene CardHHAT
Uniprot IDQ5VTY9
PfamPF03062
In ASDno
Allosteric Predictionno (-0.668483645)
Ortholog in AnimalsAlpaca_ HHAT ( ortholog_one2one )
Dog_ HHAT ( ortholog_one2one )
GuineaPig_ HHAT ( ortholog_one2one )
Macaque_ HHAT ( ortholog_one2one )
Mouse_ Hhat ( ortholog_one2one )
Pig_ HHAT ( ortholog_one2one )
Rat_ Hhat ( ortholog_one2one )
Rabbit_ HHAT ( ortholog_one2one )
OhnologsHHATL
ParalogsHHATL
TissueNA
Tissue SpecificityWidely expressed. Expressed in fetal ovary and testis, with high levels of expression observed in Sertoli cells (PubMed:24784881). {ECO:0000269|PubMed:11160356, ECO:0000269|PubMed:24784881}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6P64  (X-ray  3.05A  )  6UJO  (X-ray  2.25A  )  6UJQ  (X-ray  2.55A  )  6UK2  (X-ray  3.14A  )  6UK4  (X-ray  2.70A  )  7MHY  (EM  2.70A  )  7MHZ  (EM  3.20A  )  7Q1U  (EM  2.70A  )  7Q6Z  (EM  3.59A  )  7URF  (EM  2.80A  ) 
DBSNP rs2228898  rs2294851  rs34228541  rs757163023  rs147954610 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:25488661, ECO:0000269|PubMed:25505265, ECO:0000305|PubMed:18534984};
Multi-pass membrane protein {ECO:0000269|PubMed:25488661, ECO:0000269|PubMed:25505265}. Golgi apparatus membrane {ECO:0000305|PubMed:18534984};
Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with SHH in the ER and Golgi membrane. {ECO:0000305|PubMed:18534984}.
Mouse PG classificationNA
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