| Gene Information | |
|---|---|
| Gene Name | HGSNAT |
| Organism | Homo sapiens (Human) |
| Gene Length | 663 |
| Protein Names | Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000165102 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q68CP4 |
| Gene Card | HGSNAT |
| Uniprot ID | Q68CP4 |
| Pfam | PF07786 |
| In ASD | no |
| Allosteric Prediction | no (-0.367834452) |
| Ortholog in Animals | Alpaca_ HGSNAT ( ortholog_one2one ) Dog_ HGSNAT ( ortholog_one2one ) Macaque_ HGSNAT ( ortholog_one2one ) Mouse_ Hgsnat ( ortholog_one2one ) Rat_ Hgsnat ( ortholog_one2one ) Rabbit_ HGSNAT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest level in leukocytes, heart, liver, skeletal muscle, lung, placenta and liver. {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs73569592 rs112029032 |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:17897319}. Note=Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain. |
| Mouse PG classification | LPG |
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