| Gene Information | |
|---|---|
| Gene Name | HGS |
| Organism | Homo sapiens (Human) |
| Gene Length | 777 |
| Protein Names | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) |
| Target Name | hepatocyte growth factor-regulated tyrosine kinase substrate |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000185359 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O14964 |
| Gene Card | HGS |
| Uniprot ID | O14964 |
| Pfam | PF01363; PF12210; PF00790 |
| In ASD | no |
| Allosteric Prediction | yes (0.56357936) |
| Ortholog in Animals | Alpaca_ HGS ( ortholog_one2one ) Dog_ HGS ( ortholog_one2one ) GuineaPig_ HGS ( ortholog_one2one ) Macaque_ HGS ( ortholog_one2one ) Mouse_ Hgs ( ortholog_one2one ) Pig_ HGS ( ortholog_one2one ) Rat_ Hgs ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | WDFY2, STAM2, GGA1, TOM1, WDFY1, TOM1L2, GGA3, STAM, GGA2, TOM1L1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes. {ECO:0000269|PubMed:9407053, ECO:0000269|PubMed:9630564}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.125740(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2D3G (X-ray 1.70A ) 3F1I (X-ray 2.30A ) 3OBQ (X-ray 1.40A ) 3ZYQ (X-ray 1.48A ) 4AVX (X-ray 1.68A ) |
| DBSNP | rs753682847 rs34868130 rs56058441 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q9JJ50}. Early endosome membrane {ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q9JJ50}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ50}. Note=Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments. {ECO:0000269|PubMed:16159959}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |