| Gene Information | |
|---|---|
| Gene Name | HECW1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1606 |
| Protein Names | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000002746 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q76N89 |
| Gene Card | HECW1 |
| Uniprot ID | Q76N89 |
| Pfam | PF00168; PF00632; PF18436; PF16562; PF00397 |
| In ASD | no |
| Allosteric Prediction | no (-0.701207969) |
| Ortholog in Animals | Alpaca_ HECW1 ( ortholog_one2one ) Dog_ HECW1 ( ortholog_one2one ) GuineaPig_ HECW1 ( ortholog_one2one ) Macaque_ HECW1 ( ortholog_one2one ) Mouse_ Hecw1 ( ortholog_one2one ) Pig_ HECW1 ( ortholog_one2one ) Rat_ Hecw1 ( ortholog_one2one ) Rabbit_ HECW1 ( ortholog_one2one ) |
| Ohnologs | HECW2 |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, WWP2, TRIP12, HERC5, HERC6 |
| Tissue | kidney |
| Tissue Specificity | Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney. {ECO:0000269|PubMed:14684739}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3L4H (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14684739}. |
| Mouse PG classification | NA |
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