| Gene Information | |
|---|---|
| Gene Name | HGFAC |
| Organism | Homo sapiens (Human) |
| Gene Length | 655 |
| Protein Names | Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000109758 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q04756 |
| Gene Card | HGFAC |
| Uniprot ID | Q04756 |
| Pfam | PF00008; PF00040; PF00051; PF00089 |
| In ASD | yes |
| Allosteric Prediction | yes (0.194000872) |
| Ortholog in Animals | Alpaca_ HGFAC ( ortholog_one2many ) Dog_ HGFAC ( ortholog_one2one ) GuineaPig_ HGFAC ( ortholog_one2one ) Macaque_ HGFAC ( ortholog_one2one ) Mouse_ Hgfac ( ortholog_one2one ) Pig_ HGFAC ( ortholog_one2one ) Rat_ Hgfac ( ortholog_one2one ) |
| Ohnologs | PLAT, PLAU, HABP2 |
| Paralogs | F7, C1R, KLK10, F9, F12, F10, CFI, CFD, PRSS55, PRSS51, C1S, C1RL, HP, HPR, KLKB1, F11 |
| Tissue | liver |
| Tissue Specificity | Liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1YBW (X-ray 2.70A ) 1YC0 (X-ray 2.60A ) 2R0K (X-ray 3.51A ) 2R0L (X-ray 2.20A ) 2WUB (X-ray 2.90A ) 2WUC (X-ray 2.70A ) 3K2U (X-ray 2.35A ) |
| DBSNP | rs3748034 rs16844370 rs1987546 rs16844401 rs2498323 |
| Subcellular location [CC] | Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. |
| Mouse PG classification | NA |
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