Gene Information
Gene NameHGF
OrganismHomo sapiens (Human)
Gene Length728
Protein NamesHepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]
Target Namehepatocyte growth factor
Target TypeClinical trial target
Gene Age645 ( ENSG00000019991 )
Evolutionary StageEukaryota
AlphaFoldDBP14210
Gene CardHGF
Uniprot IDP14210
PfamPF00051; PF00024; PF00089
In ASDyes
Allosteric Predictionyes (1.514908313)
Ortholog in AnimalsAlpaca_ HGF ( ortholog_one2one )
Dog_ HGF ( ortholog_one2one )
GuineaPig_ HGF ( ortholog_one2one )
Macaque_ HGF ( ortholog_one2one )
Mouse_ Hgf ( ortholog_one2one )
Pig_ HGF ( ortholog_one2one )
Rat_ Hgf ( ortholog_one2one )
Rabbit_ HGF ( ortholog_one2one )
OhnologsPLG, MST1, LPA
ParalogsGZMA, MST1, PIK3IP1, HABP2, GZMK
Tissueplacenta
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1BHT  (X-ray  2.00A  1GMN  (X-ray  2.30A  1GMO  (X-ray  3.00A  1GP9  (X-ray  2.50A  1NK1  (X-ray  2.50A  1SHY  (X-ray  3.22A  1SI5  (X-ray  2.53A  2HGF  (NMR  2QJ2  (X-ray  1.81A  3HMS  (X-ray  1.70A  3HMT  (X-ray  2.00A  3HN4  (X-ray  2.60A  3MKP  (X-ray  2.81A  3SP8  (X-ray  1.86A  4D3C  (X-ray  2.62A  4K3J  (X-ray  2.80A  4O3T  (X-ray  2.99A  4O3U  (X-ray  3.04A  5COE  (X-ray  2.18A  5CP9  (X-ray  1.90A  5CS1  (X-ray  2.00A  5CS3  (X-ray  2.50A  5CS5  (X-ray  1.90A  5CS9  (X-ray  2.00A  5CSQ  (X-ray  1.95A  5CT1  (X-ray  2.00A  5CT2  (X-ray  2.00A  5CT3  (X-ray  2.00A  7MO7  (EM  4.80A  7MO8  (EM  4.50A  7MO9  (EM  4.00A  7MOA  (EM  4.90A  7MOB  (EM  5.00A  7OCL  (X-ray  1.80A  7OCM  (X-ray  1.70A 
DBSNP rs5745687  rs5745688 
Subcellular location [CC]NA
Mouse PG classificationNA
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