| Gene Information | |
|---|---|
| Gene Name | HGD |
| Organism | Homo sapiens (Human) |
| Gene Length | 445 |
| Protein Names | Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000113924 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q93099 |
| Gene Card | HGD |
| Uniprot ID | Q93099 |
| Pfam | PF04209; PF20510 |
| In ASD | no |
| Allosteric Prediction | yes (0.058948453) |
| Ortholog in Animals | Alpaca_ HGD ( ortholog_one2one ) Dog_ HGD ( ortholog_one2one ) GuineaPig_ HGD ( ortholog_one2one ) Macaque_ HGD ( ortholog_one2one ) Mouse_ Hgd ( ortholog_one2one ) Pig_ HGD ( ortholog_one2one ) Rat_ Hgd ( ortholog_one2one ) Rabbit_ HGD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | kidney, liver |
| Tissue Specificity | Highest expression in the prostate, small intestine, colon, kidney and liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EY2 (X-ray 2.30A ) 1EYB (X-ray 1.90A ) |
| DBSNP | rs200412910 rs1458752246 rs373921680 rs1049246177 rs200808744 rs1324654414 rs1174584850 rs2255543 rs755734596 rs569846003 rs752153829 rs149165166 rs544956641 rs374473331 rs564979861 rs1553717936 rs775274569 rs375396766 rs28941783 rs780173554 rs375283568 rs756134838 rs1349543050 rs756255206 rs1414279737 rs767201131 rs562853291 rs562853291 rs1941093400 rs28942100 rs759843592 rs756522409 rs120074174 rs1160502581 rs754428438 rs120074170 rs120074171 rs764037565 rs368717991 rs765219004 rs120074173 rs765912447 rs120074172 rs138558042 rs981454067 rs767159114 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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