| Gene Information | |
|---|---|
| Gene Name | HFE |
| Organism | Homo sapiens (Human) |
| Gene Length | 348 |
| Protein Names | Hereditary hemochromatosis protein (HLA-H) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000010704 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q30201 |
| Gene Card | HFE |
| Uniprot ID | Q30201 |
| Pfam | PF07654; PF00129 |
| In ASD | no |
| Allosteric Prediction | yes (0.882130417) |
| Ortholog in Animals | Alpaca_ HFE ( ortholog_one2one ) Dog_ HFE ( ortholog_one2one ) GuineaPig_ HFE ( ortholog_one2one ) Macaque_ HFE ( ortholog_one2one ) Mouse_ Hfe ( ortholog_one2one ) Pig_ HFE ( ortholog_one2one ) Rat_ Hfe ( ortholog_one2one ) Rabbit_ HFE ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HLA-B, HLA-E, HLA-A, HLA-F, HLA-G, HLA-C, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, CD1A, CD1D, CD1C, RAET1E, ULBP3, ULBP1, CD1E, AZGP1, MICA, MICB, MR1 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested except brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.047059(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A6Z (X-ray 2.60A ) 1DE4 (X-ray 2.80A ) |
| DBSNP | rs149342416 rs28934889 rs111033557 rs1799945 rs1800730 rs747739169 rs28934597 rs28934596 rs28934595 rs4986950 rs62625346 rs140080192 rs1800562 rs111033563 rs143175221 rs111033558 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:9465039}; Single-pass type I membrane protein {ECO:0000305|PubMed:8696333}. |
| Mouse PG classification | LPG |
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