| Gene Information | |
|---|---|
| Gene Name | ATP2C1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 919 |
| Protein Names | Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) |
| Target Name | calcium transporting atpases |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000017260 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P98194 |
| Gene Card | ATP2C1 |
| Uniprot ID | P98194 |
| Pfam | PF00689; PF00690 |
| In ASD | no |
| Allosteric Prediction | yes (0.738536974) |
| Ortholog in Animals | Alpaca_ ATP2C1 ( ortholog_one2one ) Dog_ ATP2C1 ( ortholog_one2one ) GuineaPig_ ATP2C1 ( ortholog_one2one ) Macaque_ ATP2C1 ( ortholog_one2one ) Mouse_ Atp2c1 ( ortholog_one2one ) Pig_ ATP2C1 ( ortholog_one2one ) Rat_ Atp2c1 ( ortholog_one2one ) Rabbit_ ATP2C1 ( ortholog_one2one ) |
| Ohnologs | ATP2C2 |
| Paralogs | ATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP13A1 |
| Tissue | NA |
| Tissue Specificity | Found in most tissues except colon, thymus, spleen and leukocytes (PubMed:15831496). Expressed in keratinocytes (at protein level) (PubMed:15831496, PubMed:14632183). {ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:15831496}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs137853012 rs1393570830 rs41434650 rs137853014 rs1282232888 rs137853015 rs778865612 |
| Subcellular location [CC] | Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:21187401}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:21187401}; Multi-pass membrane protein {ECO:0000255}. Note=During neuron differentiation, shifts from juxtanuclear Golgi position to multiple Golgi structures distributed over the neural soma with a predominance in the apical dendritic trunk. {ECO:0000250|UniProtKB:Q80XR2}. |
| Mouse PG classification | NA |
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